Improved synthesis of quinine alkaloids with the Teoc protective group
Improved synthesis of quinine alkaloids with the Teoc protective group
复制标题
DOI：
10.1016/j.tetlet.2005.06.171
复制
发表时间：
2005-09-12
影响因子：
1.8
通讯作者：
Kobayashi, Y
中科院分区：
文献类型：
--
作者：
Igarashi, J;Kobayashi, Y
TeocCl（Teoc：C（=O）O（CH 2）（2）TMS）方便地用于将N-Bn哌啶中间体反式保护为N-Teoc哌啶。随后，Teoc基团的脱保护和随后的奎宁环形成用CsF以多米诺骨牌方式实现，得到奎宁生物碱。(c)2005爱思唯尔有限公司保留所有权利。
TeocCl (Teoc: C(=O)O(CH2)(2)TMS) generated in situ was conveniently used for trans-protection of the N-Bn piperidine intermediate to N-Teoc piperidine. Later, deprotection of the Teoc group and the subsequent quinuclidine ring formation was achieved with CsF in a domino fashion to afford the quinine alkaloids. (c) 2005 Elsevier Ltd. All rights reserved.