Outlining the keyword co-occurrence trends in Shuanghuanglian injection research: A bibliometric study using CiteSpace III
Outlining the keyword co-occurrence trends in Shuanghuanglian injection research: A bibliometric study using CiteSpace III
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DOI：
10.1016/j.jtcms.2020.05.006
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发表时间：
2020-06-04
影响因子：
--
通讯作者：
Fang J
中科院分区：
文献类型：
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作者：
Zhang Q;Rong G;Meng Q;Yu M;Xie Q;Fang J
目的：探讨双黄连注射剂的用药演变及新趋势。应用计算机检索中国国家知识基础设施数据库、PubMed、Embase数据库，检索词“双黄连注射剂”和“双黄连芬珍”，并限定文章语言种类为1992年至2020年。两位作者对检索到的文章进行了进一步调查，排除了与SHLI无关的文章。纳入文章的参考文献被作为原始数据输出，然后使用CiteSpace工具进行处理，以可视化SHLI研究领域的地图。对基本聚类和高频关键词进行了量化，以供进一步分析。用TF-∗-IDF算法对聚类进行自动标记，以进行客观分析。还确定并讨论了基本的文献计量学特征，包括文章类型和文章数量的年度趋势。感兴趣关键词的模块具有很高的模块化分数(Q=100.73)，边界清晰。确定了高置信度聚类，包括生物活性指纹图谱(S=60.99)、均匀瞳孔(S=60.91)、制剂科(S=60.87)、呼吸困难(S=60.85)、蠕动(0.88)、丹参粉针(S=90.94)。频度和突发性特征关键词分别为注射用双黄连粉针剂(F=9235，B=95.22)、SHLI(F=1112，B=111.39)、药品不良反应(ADRs；F=104B=77.35)。在SHLI研究领域，主要有五大类：生物活性指纹图谱；ADR机制和病因检测；适当的准备；临床证据积累；以及对未有效治疗和联合使用的疾病的疗效。从科学的角度使用现代方法研究卫生与生命科学的趋势将继续存在。多因素不良反应的原因可能是未来研究的一个重要课题。
To explore the evolvement and new trends in the use of Shuanghuanglian injection (SHLI). China National Knowledge Infrastructure (CNKI), PubMed, and Embase were extensively searched using the search terms “Shuanghuanglian injection” and “Shuanghuanglian fenzhen” to retrieve articles relevant to SHLI (1992–2020). Retrieved articles were further investigated by two authors to exclude those unrelated to SHLI. The bibliographical references of the included articles were exported as raw data and then treated using the CiteSpace tool to visualize the mapping of the SHLI research domain. Essential clusters and highly frequent keywords were quantified for further analysis. The clusters were automatically labeled by the algorithm of tf∗idf for objective analysis. Basic bibliometric features, including article types and yearly trend in article numbers were also determined and discussed. The modules of the keywords of interest presented clear boundaries with a high modularity score (Q = 0.73). High-confidence clusters were identified, including bioactivity fingerprint (S = 0.99), equal pupils (S = 0.91), drug preparation department (S = 0.87), difficulty in respiration (S = 0.85), peristalsis (0.88), and Danshen powder injection (S = 0.94). The characteristic keywords in terms of frequency and burstiness were Shuanghuanglian powder for injection (F = 235, B = 5.22), SHLI (F = 112, B = 11.39), and adverse drug reactions (ADRs; F = 104, B = 7.35). In the field of SHLI study, there are five major topic categories: bioactivity fingerprint; ADR mechanism and cause detection; proper preparation; clinical evidence accumulation; and efficacy in diseases with no effective treatment and combination usage. The trend for using modern methodologies from a science-based perspective to study SHLI will continue to exist. The causes of multi-factorial ADRs may be an important topic for future studies.