Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients
Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients
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DOI：
10.1097/01.psy.0000074003.35911.41
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发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Goodey, E
中科院分区：
文献类型：
--
作者：
Carlson, LE;Speca, M;Goodey, E
目的：这项研究调查了早期乳腺癌和前列腺癌患者基于正念的减压冥想计划与生活质量、情绪状态、应激症状、淋巴细胞计数和细胞因子产生的关系。方法：49名乳腺癌患者和10名前列腺癌患者参加了为期8周的MBSR项目，其中包括放松、冥想、温和的瑜伽和日常的家庭练习。观察干预前后患者的生活质量(EORTC QLQ C-30)、情绪(POMS)、应激(SOSI)、NK、NKT、13、T细胞总数、辅助性T细胞和T细胞毒细胞计数，以及NK和T细胞产生的肿瘤坏死因子、干扰素-γ、IL-4和IL-10。结果：59 42例患者分别在干预前和干预后进行评估。总体生活质量、压力症状和睡眠质量都有了显著改善。虽然淋巴细胞总数和细胞亚群没有明显变化，但IL-4的T细胞产生增加，而IL-10的NK细胞产生减少。这些结果与免疫特征从与抑郁症状相关的改变到更正常的特征是一致的。结论：在乳腺癌和前列腺癌患者中，MBSR的参与与生活质量的提高和压力症状的减少有关。这项研究也是第一次显示癌症相关细胞因子产生的变化与项目参与有关。
Objectives: This study investigated the relationships between a mindfulness-based stress reduction meditation program for early stage breast and prostate cancer patients and quality of life, mood states, stress symptoms, lymphocyte counts, and cytokine production. Methods: Forty-nine patients with breast cancer and 10 with prostate cancer participated in an 8-week MBSR program that incorporated relaxation, meditation, gentle yoga, and daily home practice. Demographic and health behavior variables, quality of life (EORTC QLQ C-30), mood (POMS), stress (SOSI), and counts of NK, NKT, 13, T total, T helper, and T cytotoxic cells, as well as NK and T cell production of TNF, IFN-gamma, IL-4, and IL-10 were assessed pre- and postintervention. Results: Fifty-nine and 42 patients were assessed pre- and postintervention, respectively. Significant improvements were seen in overall quality of life, symptoms of stress, and sleep quality. Although there were no significant changes in the overall number of lymphocytes or cell subsets, T cell production of IL-4 increased and IFN-gamma decreased, whereas NK cell production of IL-10 decreased. These results are consistent with a shift in immune profile from one associated with depressive symptoms to a more normal profile. Conclusions: MBSR participation was associated with enhanced quality of life and decreased stress symptoms in breast and prostate cancer patients. This study is also the first to show changes in cancer-related cytokine production associated with program participation.