Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis
Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis
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DOI：
10.1021/np070246i
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Nantikoshi, Michio
中科院分区：
文献类型：
--
作者：
Tsukamoto, Sachiko;Kawabata, Tetsuro;Nantikoshi, Michio
从采自印度尼西亚北苏拉威西岛的海绵Leucetta chagosensis中分离得到两个新的咪唑类生物碱，Naamidines H（1）和1（2）。化合物（1和2）显示出对HeLa细胞的细胞毒性，IC 50值分别为5.6和15 μ g/mL。
Two new imidazole alkaloids, naamidines H (1) and 1 (2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds (1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 mu g/mL, respectively.