Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: a case report
Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: a case report
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DOI：
10.1186/s12883-020-01744-x
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发表时间：
2020-04-29
期刊：
影响因子：
2.6
通讯作者：
Hori, Tomokatsu
中科院分区：
文献类型：
--
作者：
Abe, Keiichi;Yamaguchi, Toshio;Hori, Tomokatsu
背景 我们报告了第一例经颅磁共振引导聚焦超声（MRgFUS）治疗内侧颞叶癫痫（MTLE）的病例。病例介绍 目标位于中线外侧 20 毫米、颅底上方 15 毫米（左海马体）。尽管施加了最大能量，烧蚀温度并未超过 50 摄氏度，这可能是因为入射角低于 25 度的有效换能器元件数量较少。颅骨密度比为0.56。术后磁共振成像没有发现任何病变，患者在长达 12 个月的时间里几乎没有癫痫发作。结论 该初步病例报告表明 MRgFUS 可能对治疗 MTLE 病例有效。因此，MRgFUS的安全性和可行性应在未来更多参与者和更长随访时间的研究中进行评估。
Background We report the first case of transcranial magnetic resonance-guided focused ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE). Case presentation The target was located 20 mm lateral from the midline and 15 mm above the skull base (left hippocampus). Despite the application of maximal energy, the ablation temperature did not exceed 50 degrees C, probably because of the low number of effective transducer elements with incident angles below 25 degrees. The skull density ratio was 0.56. Post-operative magnetic resonance imaging did not reveal any lesion and the patient remained almost seizure-free for up to 12 months. Conclusions This preliminary case report suggests that MRgFUS may be effective for treating cases of MTLE. Therefore, the safety and feasibility of MRgFUS should be evaluated in future studies with larger numbers of participants and longer follow-up duration.