Cocrystal Formation from Solvent Mixtures
Cocrystal Formation from Solvent Mixtures
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DOI：
10.1021/cg100361y
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发表时间：
2010-06
影响因子：
3.8
通讯作者：
T. Rager;R. Hilfiker
中科院分区：
文献类型：
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作者：
T. Rager;R. Hilfiker
溶剂混合物可用于热力学抑制溶剂化物的形成，作为基于溶液的共结晶实验中的竞争反应。这已在多达九种不同的溶剂化溶剂存在下成功地证明了卡马西平和糖精的共结晶，并通过与其他 18 种已知的卡马西平共晶形成剂的共结晶实验进行了进一步测试。研究发现，这种方法成功的机会随着混合物中溶剂数量的增加而增加。另外还观察到溶剂混合物可用于消除不同化合物之间的溶解度差异。
Solvent mixtures can be used to thermodynamically suppress solvate formation as a competing reaction in solution-based cocrystallization experiments. This has been demonstrated successfully for the cocrystallization of carbamazepine and saccharin in the presence of up to nine different solvate-forming solvents and was further tested by cocrystallization experiments with 18 other known cocrystal formers of carbamazepine. It was found that the chances of success of this approach increase with the number of solvents in the mixture. It was additionally observed that solvent mixtures can be used to level out the solubility differences between different compounds.