Valued Living and Its Relationship to Medication Adherence in Patients with Bipolar and Comorbid Substance Use Disorders.
Valued Living and Its Relationship to Medication Adherence in Patients with Bipolar and Comorbid Substance Use Disorders.
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DOI：
10.1097/nmd.0000000000000533
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Miller IW
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文献类型：
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作者：
Gaudiano BA;Wenze SJ;Weinstock LM;Tezanos KM;Miller IW
双相情感障碍合并药物滥用与治疗不依从率高相关。迄今为止开发的依从性干预措施在这一人群中效果好坏参半。有价值的生活（即患者的个人价值观和日常行为之间的一致性）代表了一个潜在的有用的治疗目标，可以提高依从性。我们调查了39例诊断为双相情感障碍和共病物质使用障碍的患者样本中有价值的生活、药物依从性、症状和功能之间的关系。结果显示，即使在控制了症状严重程度、功能损害和其他报告的不依从性原因后，更大的值-作用一致性解释了药物依从性的独特方差（R2变化= 15.2%）。药物使用和治疗信念也预示着不依从。研究结果表明，在未来的依从性干预研究中，有价值的生活应该作为一个潜在的可延展性治疗目标进行进一步的研究。
Bipolar disorder with comorbid substance abuse is associated with high rates of treatment nonadherence. Adherence interventions developed to date have had mixed effects in this population. Valued living (i.e., the consistency between a patient’s personal values and daily actions) represents a potentially useful treatment target that may improve adherence. We investigated the relationship between valued living, medication adherence, symptoms, and functioning in a sample of 39 patients diagnosed with bipolar disorder and a comorbid substance use disorder. Results showed that greater values-action consistency explained a unique amount of variance (R2 Change = 15.2%) in medication adherence even after controlling for symptom severity, functional impairment, and other reported reasons for nonadherence. Drug use and treatment beliefs also predicted nonadherence. Findings suggest that valued living should be investigated further as a potentially malleable treatment target in future adherence intervention research.