THERMOTOLERANCE AND EXTENDED LIFE-SPAN CONFERRED BY SINGLE-GENE MUTATIONS AND INDUCED BY THERMAL-STRESS
THERMOTOLERANCE AND EXTENDED LIFE-SPAN CONFERRED BY SINGLE-GENE MUTATIONS AND INDUCED BY THERMAL-STRESS
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DOI：
10.1073/pnas.92.16.7540
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发表时间：
1995-08-01
影响因子：
11.1
通讯作者：
JOHNSON, TE
中科院分区：
文献类型：
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作者：
LITHGOW, GJ;WHITE, TM;JOHNSON, TE
我们已经发现，线虫秀丽隐杆线虫的三个长寿突变体也表现出增加的内在耐热性（Itt）作为年轻的成年人。age-1基因的突变不仅导致预期寿命延长65%，而且还导致Itt。Itt表型与年龄-1共分离。长寿命的spe-26和daf-2突变体也表现出Itt。我们通过开发环境诱导耐热性的条件，研究了耐热性增加和寿命延长之间的关系。这种预处理在亚致死温度诱导显着增加耐热性和小，但统计学上高度显着增加预期寿命，这两个性状之间的因果关系相一致。因此，当动物对压力的抵抗力增加时，无论是通过遗传还是环境操纵，我们也观察到预期寿命的增加。这些结果表明，对压力的反应能力限制了C。在其他后生动物中也可能如此。
We have discovered that three longevity mutants of the nematode Caenorhabditis elegans also exhibit increased intrinsic thermotolerance (Itt) as young adults. Mutation of the age-1 gene causes not only 65% longer life expectancy but also Itt. The Itt phenotype cosegregates with age-1. Long-lived spe-26 and daf-2 mutants also exhibit Itt. We investigated the relationship between increased thermotolerance and increased life-span by developing conditions for environmental induction of thermotolerance. Such pretreatments at sublethal temperatures induce significant increases in thermotolerance and small but statistically highly significant increases in life expectancy, consistent with a causal connection between these two traits. Thus, when an animal's resistance to stress is increased, by either genetic or environmental manipulation, we also observe an increase in life expectancy. These results suggest that ability to respond to stress limits the life expectancy of C. elegans and might do so in other metazoa as well.