MnSOD Val16Ala polymorphism and prostate cancer susceptibility: a meta-analysis involving 8,962 Subjects
MnSOD Val16Ala polymorphism and prostate cancer susceptibility: a meta-analysis involving 8,962 Subjects
复制标题
DOI：
10.1007/s00432-009-0742-x
复制
发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Chen, Qing
中科院分区：
文献类型：
--
作者：
Mao, Chen;Qiu, Li-Xin;Chen, Qing
关于锰超氧化物歧化酶（MnSOD）瓦尔（16）Ala多态性与前列腺癌（PCA）风险之间的关联，已发表的数据尚无定论。为了更精确地估计它们之间的关联，进行了荟萃分析，检索了PubMed和Embase。检索了所有合格的研究。与瓦尔/Ala对比瓦尔/瓦尔相关的PCA风险的合并比值比（OR）和95%置信区间（CI），Ala/Ala与瓦尔/瓦尔，优势模型（Ala/Ala +瓦尔/Ala vs.瓦尔/瓦尔）和隐性模型（Ala/Ala vs.瓦尔/Ala +瓦尔/瓦尔），共纳入12个研究，共8,962例受试者。总体而言，荟萃分析表明，当所有符合条件的研究合并到荟萃分析中时，显著升高的癌症风险与Ala变异基因型相关（对于瓦尔/Ala vs.瓦尔/瓦尔：OR = 1.11，95% CI = 1.00-1.24;对于Ala/Ala vs.瓦尔/瓦尔：OR = 1.22，95% CI = 1.00-1.49;对于显性模型：OR = 1.14，95%CI = 1.03-1.26）。在按种族进行的亚组分析中，发现具有Ala等位基因的高加索人的风险增加具有统计学意义（对于瓦尔/Ala vs.瓦尔/瓦尔：OR = 1.12，95% CI = 1.00-1.25;对于显性模型：OR = 1.14，95% CI = 1.02-1.26）。Meta分析结果提示，MnSOD基因的Ala等位基因是PCA发生的低风险易感基因，尤其是在白种人中。
Published data on the association between manganese superoxide dismutase (MnSOD) Val(16)Ala polymorphism and prostate cancer (PCA) risk are inconclusive. To derive a more precise estimate of the association between them, a meta-analysis was performed.PubMed and Embase were searched. All eligible studies were retrieved. The pooled odds ratio (OR) with 95% confidence interval (CI) for PCA risk associated with Val/Ala versus Val/Val, Ala/Ala versus Val/Val, dominant model (Ala/Ala + Val/Ala vs. Val/Val), and recessive model (Ala/Ala vs. Val/Ala + Val/Val) were estimated, respectively.A total of 12 studies including 8,962 subjects were involved in this meta-analysis. Overall, the meta-analysis indicated that significantly elevated cancer risk was associated with Ala variant genotype when all the eligible studies were pooled into the meta-analysis (for Val/Ala vs. Val/Val: OR = 1.11, 95% CI = 1.00-1.24; for Ala/Ala vs. Val/Val: OR = 1.22, 95% CI = 1.00-1.49; for dominant model: OR = 1.14, 95% CI = 1.03-1.26). In the subgroup analysis by ethnicity, statistically significant increased risks were found among Caucasians with Ala allele (for Val/Ala vs. Val/Val: OR = 1.12, 95% CI = 1.00-1.25; for dominant model: OR = 1.14, 95% CI = 1.02-1.26). However, no significant associations were found in Africans.This meta-analysis suggests that the Ala allele of the MnSOD gene was a low-penetrance susceptible gene in PCA development, especially in Caucasians.