Apolipoprotein A-1 is a negative target of v-Jun overexpression.
Apolipoprotein A-1 is a negative target of v-Jun overexpression.
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载脂蛋白 A-1 是 v-Jun 过度表达的负靶标。
DOI：
10.1038/sj.onc.1201574
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Bos,TJ
中科院分区：
文献类型：
--
作者：
Hadman,M;Lin,W;Bush,L;Bos,TJ
The product of the Jun oncogene influences a variety of processes including cell proliferation and differentiation. Jun exerts its influence by binding to the promoter and enhancer regions of a number of different target genes resulting in their activation or repression. We describe here the isolation and characterization of a gene differentially downregulated upon overexpression of v-Jun but not c-Jun. DNA and amino acid homology search analysis revealed this gene to be identical to chicken apolipoprotein A-1, the major component of high density lipoprotein (HDL). The half life of apolipoprotein A-1 RNA remains constant in the presence or absence of v-Jun overexpression suggesting downregulation by v-Jun is at the level of promoter activity. Consistent with this hypothesis, apolipoprotein A-1 upstream promoter fragments active in normal and c-Jun expressing CEF are inactive in v-Jun transformed CEF. Analysis of expression of apolipoprotein A-1 in CEF overexpressing other oncogenes revealed a similar downregulation by Myc and v-Src but not c-Fos, v-Ha-Ras, c-Src or c-Ski. Our findings point to a potential regulatory affect on cholesterol metabolism by v-Jun, as a result of altered levels of apolipoprotein A-1 message expression.
