Iodine-Promoted Multicomponent Synthesis of 2,4-Diamino-1,3,5-triazines
Iodine-Promoted Multicomponent Synthesis of 2,4-Diamino-1,3,5-triazines
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碘促进 2,4-二氨基-1,3,5-三嗪的多组分合成
DOI：
10.1021/acs.orglett.0c03130
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Wu An-Xin
中科院分区：
文献类型：
--
作者：
Zhao Peng;Zhou You;Yu Xiao-Xiao;Huang Chun;Wu Yan-Dong;Yin Guodong;Wu An-Xin
报道了一种新颖而有效的甲基酮、氰胺和芳胺的多组分环化反应，通过四个C-N键的连续形成合成了2，4-二氨基-1，3，5-三嗪。这种多组分反应的特点是使用两个氰胺分子进行甲基酮的双C(SP3)-H胺化反应，避免了复杂的底物前处理，扩大了底物范围。此外，这种多组分的环化策略为在温和的条件下合成多种2，4-二氨基-1，3，5-三嗪提供了一种新的方法，底物范围广。
A novel and efficient multicomponent cyclization of methyl ketones, cyanamides, and arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation of four C–N bonds is reported. This multicomponent reaction is characterized by the employment of two molecules of cyanamide for double C(sp3)–H amination of methyl ketones, avoiding complicated prepreparation of substrates and expanding the substrate scope. Furthermore, this multicomponent cyclization strategy provides a new approach for generating diverse 2,4-diamino-1,3,5-triazines with a broad substrate scope under mild conditions.