IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection
IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection
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IgE 抗体和对感染的抵抗力。
DOI：
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发表时间：
1981
影响因子：
15.3
通讯作者：
John R. David
中科院分区：
文献类型：
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作者：
Wendy L. Parker;Stephanie L. James;John R. David
通过注射兔抗大鼠epsilon链抗体，实现了对大鼠总IgE抗体应答的选择性抑制。这种特异性的IgE抑制在旋毛虫自然感染的过程中保持不变。免疫球蛋白E抗体反应的耗尽导致被包裹在横纹肌中的旋毛虫幼虫所吸引的嗜酸性粒细胞数量显著减少。旋毛虫感染后的嗜酸性粒细胞增多，尽管达到了正常的峰值水平，但在IgE抑制的动物中被缩短了。此外，免疫球蛋白E耗尽的动物更容易受到感染；它们肌肉中包囊的幼虫比它们的对照幼崽多两到三倍。
Selective suppression of the total IgE antibody response has been achieved in rats by injection of rabbit anti-rat epsilon-chain antibodies. This IgE-specific suppression was maintained during the course of a natural infection by the nematode Trichinella spiralis. Depletion of the IgE antibody response resulted in a marked reduction of the number of eosinophils attracted to the T. spiralis larvae encysted in striated muscle. Blood eosinophilia following T. spiralis infection, although reaching normal peak levels, was abbreviated in IgE- suppressed animals. Moreover, IgE-depleted animals were more susceptible to the infection; they harbored two to three times more larvae encysted in their muscles than their control litter mates.