NOVEL ANTITUMOR ANTIBIOTICS, CI-940 (PD 114,720) AND PD 114,721 - TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITY
NOVEL ANTITUMOR ANTIBIOTICS, CI-940 (PD 114,720) AND PD 114,721 - TAXONOMY, FERMENTATION AND BIOLOGICAL-ACTIVITY
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DOI：
10.7164/antibiotics.38.460
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
LENZINI, MD
中科院分区：
文献类型：
--
作者：
TUNAC, JB;GRAHAM, BD;LENZINI, MD
新型广谱抗肿瘤抗生素CI-940（PD 114，720）和PD 114，721是由新型放线菌（ATCC 39366）产生的生物活性化合物的组分。该生物体的独特之处在于全细胞分析显示LL-二氨基庚二酸和大量的阿拉伯糖。这些新的抗生素在体外和体内对一系列肿瘤表现出有效的抗肿瘤活性，并具有很强的抗菌和抗真菌活性。上述抗生素在7570-L发酵罐中以约100%的产率生产。5-8μ g/ml。
The novel, broad-spectrum antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721, are components of bioactive compounds produced by a novel actinomycete (ATCC 39366). The organism is unique in that whole cell analysis revealed LL-diaminopimelic acid and major amounts of arabinose. These new antibiotics exhibit potent antitumor activity in vitro and in vivo vs. an array of tumors and possess strong antibacterial and antifungal activity. The above antibiotics are produced in 7570-l fermentors at yields of .apprx. 5-8 .mu.g/ml.