Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women
Association between HDL-cholesterol and the Taq1B polymorphism in the cholesterol ester transfer protein gene in obese women
复制标题
DOI：
10.1016/s0021-9150(01)00733-x
复制
发表时间：
2002-06-01
期刊：
影响因子：
5.3
通讯作者：
Clifton, PM
中科院分区：
文献类型：
--
作者：
Heilbronn, LK;Noakes, M;Clifton, PM
胆固醇酯转移蛋白（CETP）通过HDL-C促进胆固醇的反向转运，肥胖受试者的这种活性可能会增加。在体重正常的受试者中，CETP基因的Taq1B变体与CETP活性升高和HDL-C升高有关。本研究的目的是研究肥胖女性减肥前后Taq1B多态性与HDL-C之间的关系。共有24名女性（41名患有2型糖尿病）对Taq1B变异进行了基因分型。同时测定减肥前后的血脂、胰岛素、葡萄糖和口服葡萄糖耐量。当所有受试者一起检查时，Taq1B基因型与HDL-C无关。然而，当非糖尿病受试者按空腹胰岛素中位数划分时，在低于空腹胰岛素中位数（B1B1 1.19+/-0.07 mmol 1, B1B2 1.35+/-0.06, B2B2 1.71+/-0.09）的受试者中，Taq1B基因型与HDL-C之间存在很强的线性关联。P
Cholesterol ester transfer protein (CETP) facilitates reverse cholesterol transport via HDL-C and this activity may be increased in obese subjects, In normal weight subjects the Taq1B variant of the CETP gene is associated with loader CETP activity and higher HDL-C. The aim of this study was to examine the relationship between the Taq1B polymorphism and HDL-C in obese women before and after weight loss. A total of 24 women (41 with type 2 diabetes) were genotyped for the Taq1B variant. Plasma lipids, insulin, glucose and oral glucose tolerance were also measured before and after weight loss. When all subjects were examined together the Taq1B genotype was not associated with HDL-C. However, when non-diabetic Subjects were divided by median fasting insulin, a strong linear association was observed between Taq1B genotype and HDL-C in subjects below median for fasting insulin (B1B1 1.19+/-0.07 mmol 1, B1B2 1.35+/-0.06, B2B2 1.71+/-0.09. P