Structure, activation, and biology of calpain
Structure, activation, and biology of calpain
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DOI：
10.2337/diabetes.53.2007.s12
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发表时间：
2004-02-01
期刊：
影响因子：
7.7
通讯作者：
Sorimachi, H
中科院分区：
文献类型：
--
作者：
Suzuki, K;Hata, S;Sorimachi, H
最近通过定位克隆证明钙蛋白酶10基因的变异与2型糖尿病相关。从那时起，钙蛋白酶10的研究已经开始与糖尿病和胰岛素介导的信号传导相关。在这篇综述中，钙离子激活钙蛋白酶的机制，这是必不可少的了解其生理功能，最近的X-射线结构分析的基础上进行了讨论。此外，钙蛋白酶10的结构，不同于那些典型的mu-或m-钙蛋白酶在大多数研究中使用的特殊功能进行了总结，与钙蛋白酶的生理功能的讨论2型糖尿病。糖尿病53（补编1）：S12-S18，2004年。
Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential to understand its physiological functions, is discussed on the basis of recent X-ray structural analyses. Further, special features of the structure of calpain 10 that differ from those of typical mu- or m-calpain used in most studies are summarized together with discussion of the physiological function of calpain with respect to type 2 diabetes. Diabetes 53 (Suppl. 1):S12-S18, 2004.