Thioredoxin as a Therapeutic Target in Cerebral Ischemia.
Thioredoxin as a Therapeutic Target in Cerebral Ischemia.
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DOI：
10.2174/1381612824666180820143853
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发表时间：
2018
影响因子：
3.1
通讯作者：
Xiansi Zeng;Wen-Shuo Geng;Lei Chen;Jinjing Jia
中科院分区：
文献类型：
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作者：
Xiansi Zeng;Wen-Shuo Geng;Lei Chen;Jinjing Jia
背景脑缺血是导致残疾和死亡的常见原因。缺血性脑损伤由复杂的病理过程引起，包括氧化应激、炎症和细胞凋亡。硫氧还蛋白（Trx）是一种重要的多功能蛋白，调节细胞的氧化还原状态。越来越多的研究表明Trx对脑缺血损伤具有神经保护作用。方法系统检索PMC和PubMed数据库，总结Trx对脑缺血的保护作用。结果本文综述了Trx的抗脑缺血作用及其机制，包括抗氧化、抗凋亡、抗炎作用以及激活促生存通路。我们还总结了一些天然化合物诱导Trx的表达，这是参与其抗缺血作用。结论Trx对缺血性脑卒中具有潜在的神经保护作用，在临床治疗缺血性脑卒中中具有广阔的应用前景。
BACKGROUND Cerebral ischemia is a common cause of disability and death. Ischemic brain injury results from complex pathological processes, including oxidative stress, inflammation, and apoptosis. Thioredoxin( Trx) is an important multifunctional protein, which regulates cellular redox status. Increasing studies have demonstrated that Trx provides a neuroprotective role against cerebral ischemia-induced injury. METHODS A systematic search of PMC and the PubMed Database was conducted to summarize the protective effects of Trx against cerebral ischemia. RESULTS This article reviews the understanding of potential effects and mechanisms of Trx against cerebral ischemia, including the anti-oxidant, anti-apoptotic and anti-inflammatory effects, as well as the activation of prosurvival pathway. We also summarize that some natural compounds induce the expression of Trx, which is involved in their anti-ischemic effects. CONCLUSION In conclusion, Trx has a potential neuroprotection in cerebral ischemia and may be very promising for clinical therapy of ischemic stroke in the future.