Examination of fetal growth trajectories following infertility treatment.
Examination of fetal growth trajectories following infertility treatment.
复制标题
不孕症治疗后检查胎儿生长轨迹。
DOI：
10.1007/s10815-020-01785-8
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发表时间：
2020
影响因子：
3.1
通讯作者：
Baker,ValerieLynn
中科院分区：
文献类型：
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作者：
Besharati,Melody;vonVersen-Höynck,Frauke;Kapphahn,Kris;Baker,ValerieLynn
PurposeThe的目的是回顾性队列研究是比较胎儿生长在第二和第三个三个月的排卵诱导与宫内授精（IUI），新鲜胚胎移植（ET），冷冻胚胎移植（FET），和自发概念以下infertility. MethodsThirty一百九十五名妇女在一个单一的学术生育中心确认可行的怀孕参加。所有女性均通过治疗或诊断为不孕症后自发妊娠。入选标准包括自体单胎妊娠。排除标准包括来自供体卵母细胞的妊娠、双胞胎、不可用的超声数据和少数参与者的治疗方法。关注的主要结局是头围（HC）、腹围（AC）、HC/AC比值和估计的胎儿体重（EFW）。有条件的生长曲线模型被创建，和生长曲线被选择为每个结果的interest.ResultsFor排卵诱导与IUI，新鲜ET，FET，和自发受孕，生长曲线的斜率分析，每周的增长率HC，AC，HC/AC的比例，和EFW表现出没有差异。新鲜ET和FET组的亚组分析，相同的结果，也没有显示出任何差异。ConclusionThese研究结果有助于不孕症治疗后的胎儿生长轨迹的非常有限的文献，并建议没有显着差异，胎儿生长与IUI，新鲜ET，FET诱导排卵，不孕症后自发受孕。这些受孕方法之间的生长轨迹可能没有差异，因为大多数不孕症后出生的孩子出生体重正常。虽然结果令人放心，但需要对更大人群进行进一步研究。
PurposeThe objective of this retrospective cohort study was to compare fetal growth during the second and third trimesters for ovulation induction with intrauterine insemination (IUI), fresh embryo transfer (ET), frozen embryo transfer (FET), and spontaneous conception following infertility.MethodsThree hundred ninety-five women with viable pregnancies confirmed at a single academic fertility center participated. All women achieved pregnancy either by treatment or spontaneously after a diagnosis of infertility. Inclusion criteria included autologous singleton pregnancies. Exclusion criteria included pregnancies from donor oocytes, twins, unavailable ultrasound data, and treatment methods with small number of participants. Primary outcomes of interest were head circumference (HC), abdominal circumference (AC), HC/AC ratio, and estimated fetal weight (EFW). Conditional growth curve models were created, and growth curves were selected for each outcome of interest.ResultsFor ovulation induction with IUI, fresh ET, FET, and spontaneous conception, the slope analysis of growth curves for per-week growth rate of HC, AC, HC/AC ratio, and EFW demonstrated no difference. A subgroup analysis of fresh ET and FET groups, for same outcomes, also showed no difference.ConclusionThese findings contribute to the very limited literature on fetal growth trajectories following infertility treatment and suggest no significant differences in fetal growth for ovulation induction with IUI, fresh ET, FET, and spontaneous conception following infertility. It is possible there were no differences in growth trajectories between these conception methods because the majority of children born following infertility are of normal birth weight. While results are reassuring, further research with larger populations is warranted.