Neural reflex control of vascular inflammation.
Neural reflex control of vascular inflammation.
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DOI：
10.1186/s42234-020-0038-7
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发表时间：
2020-01-01
影响因子：
--
通讯作者：
Olofsson, P S
中科院分区：
文献类型：
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作者：
Caravaca, A S;Centa, M;Olofsson, P S
动脉粥样硬化是一种多因素慢性炎症性疾病，是心肌梗死和中风的基础。对高脂血症和高血压的有效治疗显著降低了心血管疾病的发病率和死亡率。然而，动脉粥样硬化仍然具有相当大的心血管不良事件风险。在目前对动脉粥样硬化发病机制的理解中，炎症在疾病的发生和进展中都是关键的。最近的临床数据为这一概念提供了支持，目前正在探索针对炎症的治疗。有趣的是，神经反射调节细胞因子的产生和炎症。因此，目前正在研究利用植入式装置传递电脉冲来激活神经回路的新技术，以治疗炎症。希望利用生物电子医学靶向心血管疾病的血管炎症成为可能。在这篇综述中，我们讨论炎症的神经控制和治疗心血管疾病的新治疗策略的潜在意义。
Atherosclerosis is a multifactorial chronic inflammatory disease that underlies myocardial infarction and stroke. Efficacious treatment for hyperlipidemia and hypertension has significantly reduced morbidity and mortality in cardiovascular disease. However, atherosclerosis still confers a considerable risk of adverse cardiovascular events. In the current mechanistic understanding of the pathogenesis of atherosclerosis, inflammation is pivotal both in disease development and progression. Recent clinical data provided support for this notion and treatment targeting inflammation is currently being explored. Interestingly, neural reflexes regulate cytokine production and inflammation. Hence, new technology utilizing implantable devices to deliver electrical impulses to activate neural circuits are currently being investigated in treatment of inflammation. Hopefully, it may become possible to target vascular inflammation in cardiovascular disease using bioelectronic medicine. In this review, we discuss neural control of inflammation and the potential implications of new therapeutic strategies to treat cardiovascular disease.