The effect of temperature on the potentiation of adrenalin by thyroxine in the albino rat.
The effect of temperature on the potentiation of adrenalin by thyroxine in the albino rat.
复制标题
温度对白化大鼠甲状腺素增强肾上腺素的影响。
作者：
H. E. Swanson
以前的一篇论文(1)表明，在30℃的环境温度下，甲状腺切除抑制了肾上腺素的生热作用，而注射甲状腺素则增强了肾上腺素的生热作用，这种增强作用与每日甲状腺激素的剂量成正比。鉴于寒冷对新陈代谢的极大刺激以及这两种激素在这一反应中的有争议的作用，重新研究短期或长期寒冷暴露期间这两种激素的恒定剂量之间的相互关系似乎是有意义的。由于动物突然暴露在接近冰点的温度下，代谢率增加了两到三倍，这主要归因于肌肉活动(2，3)，其次是肾上腺素分泌(4，5，6，7，8)。另一方面，冷适应的特征是保持正常的直肠温度(2，9，10，11)和对更严寒的更强抵抗力(12，13，14)，这在很大程度上与甲状腺活动增加(5，15，16)有关。
IT WAS shown in a previous paper (1) that at 30° C, ambient temperature, thyroidectomy inhibits and injected thyroxine potentiates the calorigenic action of adrenalin, the potentiation being proportional to the daily thyroxine dose. In view of the great stimulation of metabolism by cold and the disputed role of the two hormones in this response, it seemed of interest to re-examine the interrelation between constant doses of the two hormones during short or long cold exposure. The two- to three-fold rise in metabolic rate produced by sudden exposure of animals to near-freezing temperatures has been mainly attributed to muscular activity (2, 3), supplemented by adrenalin secretion (4, 5, 6, 7, 8). On the other hand, cold adaptation, characterized by maintenance of normal rectal temperature (2, 9, 10, 11) and greater resistance to more severe cold (12, 13, 14), is largely associated with increased thyroid activity (5, 15, 16).