Circulating Progenitor Cells is Linked to Cognitive Decline in Healthy Adults.
Circulating Progenitor Cells is Linked to Cognitive Decline in Healthy Adults.
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DOI：
10.1016/j.amjms.2015.11.009
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Quyyumi A
中科院分区：
文献类型：
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作者：
Hajjar I;Goldstein FC;Waller EK;Moss LD;Quyyumi A
认知和心血管疾病有许多共同的危险因素。血液中骨髓来源的祖细胞 (PC) 含量越高，心血管事件发生率越低，但 PC 与认知功能的关系尚不清楚。本研究的目的是评估参与队列研究的健康成年人样本中 PC 与认知之间的关联。对埃默里大学和佐治亚理工学院的员工进行了为期 4 年的随机抽样跟踪，并每年进行血管和认知评估（N = 430，平均年龄 = 49.2 岁，70% 为女性，27% 为非洲裔美国人）。使用 15 项认知测试的计算机化版本来评估认知，并使用主成分分析来得出认知得分：执行功能、记忆力和工作记忆。 PC被定义为具有特定表面标记（7种表型）的单核细胞。某个领域的认知能力下降被定义为基线时相应领域的表现低于最低四分位数。广义估计方程用于研究 PC 和认知之间的关联。基线时较高的 PC 水平与随访期间执行记忆和工作记忆领域认知能力下降的风险较低相关（所有 PC 表型的 p<0.002）。此外，随访期间 PC 的下降程度与同期所有 3 个认知领域的表现相应下降相关（全部 p<0.002）。 PC 的降低和 PC 的年度下降幅度更大与认知能力的下降程度更大有关。这些发现表明 PC 在神经认知衰老中发挥作用。
Cognitive and cardiovascular disorders share many risk factors. Higher bone-marrow derived progenitor cells (PC) in blood are associated with lower rates of cardiovascular events but the association of PC with cognitive function is unclear. The objective of this study was to assess the association between PC and cognition in a sample of healthy adults enrolled in a cohort study A random sample of employees at Emory University and Georgia Institute of Technology were followed for 4 years and underwent yearly vascular and cognitive assessment (N=430, mean age=49.2 years, 70% women, and 27% African American). Cognition was assessed using computerized versions of 15 cognitive tests and principal component analysis was used for deriving cognitive scores: executive function, memory and working memory. PC were defined as mononuclear cells with specific surface markers (7 phenotypes). Decreased cognition in a domain was defined as performing below the lowest quartile for the corresponding domain at baseline. Generalized estimating equations were used to investigate associations between PC and cognition. Higher PC levels at baseline were associated with lower risk of cognitive decline in the executive and working memory domains during the follow-up period (p<0.002 for all PC phenotypes). Further, the degree of decline in PC over the follow-up period was correlated with a corresponding decline in performances in all 3 cognitive domains over the same period (All p<0.002). Lower PC and greater yearly declines in PC are associated with greater cognitive decline. These findings suggest role for PC in neurocognitive aging.