Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum
Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum
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DOI：
10.1080/21678421.2016.1211151
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发表时间：
2016-10-01
影响因子：
2.8
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Masuda, Michihito;Senda, Joe;Sobue, Gen
我们研究了散发性肌萎缩侧索硬化（ALS）-额颞叶痴呆（FTD）连续体的常见结构和网络变化。基于额颞评估组合的聚类分析，51例散发性ALS患者被分为三组：25例ALS伴认知缺陷（ALS-CD）患者; 7例符合FTD标准（ALS-FTD）的患者; 19例ALS伴认知功能正常（ALS-NC）的患者。与对照组相比，ALS-FTD患者的灰质图像显示以下严重程度顺序的萎缩性改变：尾状头、额内侧回、丘脑、杏仁核、壳核和扣带回（峰值水平，未校正的P
We investigated common structural and network changes across the sporadic amyotrophic lateral sclerosis (ALS)-frontotemporal dementia (FTD) continuum. Based on cluster analysis using the frontotemporal assessment battery, 51 patients with sporadic ALS were subdivided into three groups: 25 patients with ALS with cognitive deficiency (ALS-CD); seven patients who satisfied FTD criteria (ALS-FTD), and 19 patients with ALS with normal cognitive function (ALS-NC). Compared with the controls, gray matter images from patients with ALS-FTD showed atrophic changes in the following order of severity: caudate head, medial frontal gyrus, thalamus, amygdala, putamen, and cingulate gyrus (peak level, uncorrected p