MUSCLE AND WHOLE-BODY METABOLISM AFTER NOREPINEPHRINE
MUSCLE AND WHOLE-BODY METABOLISM AFTER NOREPINEPHRINE
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DOI：
10.1152/ajpendo.1994.266.6.e877
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发表时间：
1994-06-01
影响因子：
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通讯作者：
ELIA, M
中科院分区：
文献类型：
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作者：
KURPAD, AV;KHAN, K;ELIA, M
输注去甲肾上腺素（0.42 nmol.kg(-1)）的效果。采用间接量热法和前臂动静脉置管技术，对8例健康青年男性全身能量代谢（间接量热法）和前臂肌肉的最小值（-1）进行了评估。主要作用于非肌肉组织的甘油三酯-脂肪酸循环的活性也通过使用[H-2(5)]甘油（表示脂肪分解）和间接量热法（表示净脂肪氧化）测量甘油周转量来评估。去甲肾上腺素使全身耗氧量增加近10% (P < 0.01)，但肌肉耗氧量有降低的趋势。去甲肾上腺素对肌肉血流量（x -133测量）和前臂血流量（应变计体积描记仪测量）无显著影响，但对非酯化脂肪酸和β -羟基丁酸的摄取率增加了数倍（P < 0.05），而葡萄糖的摄取率则无显著影响。在给药去甲肾上腺素后，甘油三酯-脂肪酸循环的活性增加了四倍，对静息能量消耗有边际影响（约1.5%），但占全身能量消耗增加的约15%。本研究没有证据表明骨骼肌是去甲肾上腺素诱导的产热的重要部位，并表明甘油三酯-脂肪酸循环活性的增加有助于去甲肾上腺素诱导的非肌肉组织能量消耗的增加。
The effect of an infusion of norepinephrine (0.42 nmol.kg(-1).min(-1)) on energy metabolism in the whole body (using indirect calorimetry) and forearm muscle was assessed by using indirect calorimetry and the arteriovenous forearm catheterization techniques in eight healthy young male adults. The activity of the triglyceride-fatty acid cycle, which mainly operates in nonmuscular tissues, was also assessed by measuring glycerol turnover using [H-2(5)]glycerol (to indicate lipolysis) and indirect calorimetry (to indicate net fat oxidation). Norepinephrine increased whole body oxygen consumption by almost 10% (P < 0.01), but the estimated oxygen consumption of muscles tended to decrease. Muscle blood flow (measured by Xe-133) and forearm blood flow (measured by strain-gauge plethysmography) were not significantly affected by norepinephrine, but the rate of uptake of nonesterified fatty acids and beta-hydroxybutyrate increased severalfold (P < 0.05), whereas that of glucose did not. The activity of the triglyceride-fatty acid cycle increased fourfold after norepinephrine administration, having a marginal effect on resting energy expenditure (similar to 1.5%) but accounting for similar to 15% of the increase in whole body energy expenditure. This study provides no evidence that skeletal muscle is an important site for norepinephrine-induced thermogenesis and suggests that an increase in the activity of the triglyceride-fatty acid cycle contributes to the norepinephrine-induced increase in energy expenditure of nonmuscular tissues.