A MONOCLONAL ANTIBODY TO AMYLOID IN THE BRAINS OF PATIENTS WITH ALZHEIMER'S DISEASE
A MONOCLONAL ANTIBODY TO AMYLOID IN THE BRAINS OF PATIENTS WITH ALZHEIMER'S DISEASE
复制标题
阿尔茨海默病患者大脑中淀粉样蛋白的单克隆抗体
DOI：
10.1111/j.1365-2990.1986.tb00052.x
复制
发表时间：
1986
影响因子：
5
通讯作者：
T. Saito
中科院分区：
文献类型：
--
作者：
T. Ishii;M. Sato;S. Haga;T. Shinoda;K. Kato;T. Saito
一种单克隆抗体被制造出来，它能与阿尔茨海默病患者大脑中老年斑中的淀粉样蛋白发生反应。抗原是来自原发性淀粉样变性患者脾脏的粗淀粉样蛋白（DAM，Pras et al. 1968）。该抗体与DAM交叉反应，但不染色组织切片中原发性淀粉样变性的淀粉样蛋白。假设在老年斑的淀粉样蛋白和原发性淀粉样变性的淀粉样蛋白中存在与该抗体反应的共同抗原位点。
A monoclonal antibody that reacts with the amyloid in senile plaques in the brains of patients with Alzheimer's disease, was produced. The antigen was the crude amyloid protein (DAM, Pras et al. 1968) from the spleen of a patient with primary amyloidosis. The antibody crossreacts with DAM, but does not stain the amyloid of primary amyloidosis in tissue sections. The presence of a common antigenic site or sites in both the amyloid of senile plaques and amyloid of primary amyloidosis which react with this antibody is postulated.