Modification of Polydimethylsiloxane Surfaces Using Benzophenone
Modification of Polydimethylsiloxane Surfaces Using Benzophenone
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DOI：
10.1163/156856208x397901
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发表时间：
2009-01-01
影响因子：
3.6
通讯作者：
Schacht, Etienne
中科院分区：
文献类型：
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作者：
De Smet, Nele;Rymarczyk-Machal, Monika;Schacht, Etienne
通过对聚二甲基硅氧烷（PDMS）表面进行不同的改性，获得了新的生物相容性材料。PDMS对于几种生物医学应用具有极大的兴趣。对于某些应用，天然有机硅不能提供最佳性能。PDMS吸引蛋白质和盐。为了减少蛋白质粘附和盐沉积，通过自由基聚合将选定的单体接枝到有机硅表面上。优化了以二苯甲酮为紫外光引发剂对PDMS进行表面改性的条件。使用不同的方法，改性的表面进行了表征。在体外模型中测试表面改性对作为模型蛋白的白蛋白沉积的影响。(C)Koninklijke Brill NV，莱顿，2009年
New biocompatible materials have been obtained by different modifications of polydimethylsiloxane (PDMS) surfaces. PDMS is of great interest for several biomedical applications. For some applications the native silicone does not provide an optimal performance. PDMS attracts proteins and salts. To reduce protein adhesion and salt deposition selected monomers were grafted by radical polymerization on the silicone surface. The conditions for surface modifications of PDMS using benzophenone as UV initiator were optimized. The modified surfaces were characterized properly using different methods. The effect of surface modifications on the albumin, as model protein, deposition was tested in an in vitro model. (C) Koninklijke Brill NV, Leiden, 2009