A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers
A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers
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DOI：
10.1093/aje/kwj253
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发表时间：
2006-10-01
影响因子：
5
通讯作者：
Stolzenberg-Solomon, Rachael
中科院分区：
文献类型：
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作者：
Bowers, Katherine;Albanes, Demetrius;Stolzenberg-Solomon, Rachael
2型糖尿病与结直肠癌有共同的危险因素，并已显示出与结直肠癌的正相关性。人体测量指标（身高、体重和体重指数（体重（kg）/身高（m）（2））和与胰岛素抵抗综合征（IRS）相关的代谢异常）前瞻性评估了（测量的血压、高密度脂蛋白（HDL）胆固醇和总胆固醇异常）与结肠（n = 227）、直肠（n = 183）在1985年至2002年期间，在28，983名芬兰男性吸烟者中诊断出的α-生育酚，β-胡萝卜素癌症预防研究中的癌症和结肠直肠癌（n = 410）。使用考克斯比例风险模型计算风险比和95%置信区间。与最低的五分位数相比，体重指数最高的五分位数与结直肠癌显著相关（风险比（HR）= 1.70，95%置信区间（CI）：1.01，2.85; p趋势= 0.01），尤其是结肠癌。患有三种IRS相关疾病的受试者（高血压，体重指数>= 25 kg/m2，HDL胆固醇水平< 40 mg/dl）（< 1.55毫摩尔/升）），与条件较少的人相比，患结直肠癌的风险显著增加（HR = 1.40，95% CI：1.12，1.74），尤其是结肠癌（HR = 1.58，95% CI：1.18，2.10），但不是直肠癌。这些结果支持以下假设：IRS定义的代谢异常与结直肠癌之间观察到的显著关联主要由肥胖决定。
Type 2 diabetes mellitus shares risk factors for and has shown a positive association with colorectal cancer. Anthropometric measures (height, weight, and body mass index (weight (kg)/height (m)(2)) and metabolic abnormalities associated with insulin resistance syndrome (IRS) (abnormalities in measured blood pressure, high density lipoprotein (HDL) cholesterol, and total cholesterol) were prospectively evaluated for associations with incident colon (n = 227), rectal (n = 183), and colorectal (n = 410) cancers diagnosed between 1985 and 2002 in 28,983 Finnish male smokers from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals. In comparison with the lowest quintile, the highest quintile of body mass index was significantly associated with colorectal cancer (hazard ratio (HR) = 1.70, 95% confidence interval (CI): 1.01, 2.85; p-trend = 0.01), particularly colon cancer. Subjects with a cluster of three IRS-related conditions (hypertension, body mass index >= 25 kg/m(2), and HDL cholesterol level < 40 mg/dl (< 1.55 mmol/liter)), compared with those with fewer conditions, had a significantly increased risk of colorectal cancer (HR = 1.40, 95% CI: 1.12, 1.74), particularly colon cancer (HR = 1.58, 95% CI: 1.18, 2.10), but not rectal cancer. These results support the hypothesis that the significant association observed between IRS-defining metabolic abnormalities and colorectal cancer is determined primarily by adiposity.