Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats.
Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats.
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一些抗高血压药和促尿酸排泄药物在接受奥沙酸盐治疗的大鼠中诱发高尿酸血症。
DOI：
10.1254/jjp.30.829
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
K. Iwaki
中科院分区：
文献类型：
--
作者：
Y. Yonetani;M. Ishii;K. Iwaki
本文研究了抗高血压和促尿酸药物对氧磷酯处理大鼠血浆和尿液尿酸水平的影响。我们利用动物与导管插入主动脉成功地收集血液样本，这一过程简化了血浆尿酸的渐进性变化的评价，连续加载下与氧嗪酸钾。即使单次给予利尿剂氯噻嗪、呋塞米、二氮嗪以及促尿酸药物（如替尼酸和丙磺舒），氧磷酯治疗大鼠的血浆尿酸水平也会升高。另一方面，在给予别嘌呤醇和氧钾的大鼠中，外源性给予尿酸也能产生维持良好的血浆尿酸水平。二氮嗪，噻苯酸和丙磺舒增加血浆尿酸，而利尿剂氯噻嗪没有。呋塞米在给药早期有降低别嘌呤醇、氧嗪酸盐和尿酸处理大鼠的血浆尿酸水平的趋势，但在几小时后通过尿酸负荷试验研究呋塞米对别嘌呤醇和氧嗪酸盐处理大鼠的影响时，呋塞米使这些水平升高。这些影响也表现为尿排泄尿酸的变化。因此，oxonate治疗的大鼠表现出急性诱导的高尿酸血症，不仅与某些抗高血压药物，但也与尿酸排泄药物。这些程序的效用进行了讨论，以评估药物的高尿酸血症和促尿酸作用。
Effects of antihypertensive and uricosuric drugs were studied on the plasma and urinary levels of uric acid in oxonate-treated rats. We made use of animals with a catheterized aorta to successfully collect blood samples and this procedure simplified the evaluation of progressive changes of plasma uric acid, under successive loading with potassium oxonate. The plasma uric acid level of the oxonate-treated rats was increased even with a single administration of diuretic chlorothiazides, furosemide, diazoxide and also uricosuric drugs such as tienilic acid and probenecid. On the other hand, a wellmaintained plasma uric acid level was also produced by exogenously administered uric acid in rats which had been given allopurinol and potassium oxonate. Diazoxide, tienilic acid and probenecid increased the plasma uric acid, while diuretic chlorothiazides did not. Furosemide tended to decrease the plasma uric acid level at the early stage of administration to rats treated with allopurinol, oxonate and uric acid, but increased these levels several hours later when the effect was studied by uric acid loading test wit rats treated with allopurinol and oxonate. These effects also appeared as changes in the urine-excreted uric acid. Thus, the oxonate-treated rats demonstrated an acutely induced hyperuricemia not only with certain antihypertensives, but also with uricosuric drugs. The utility of these procedures for evaluating the hyperuricemic and uricosuric effects of drugs is discussed.