VACCINE PROTECTION OF CHIMPANZEES AGAINST CHALLENGE WITH HIV-1 INFECTED PERIPHERAL-BLOOD MONONUCLEAR-CELLS
VACCINE PROTECTION OF CHIMPANZEES AGAINST CHALLENGE WITH HIV-1 INFECTED PERIPHERAL-BLOOD MONONUCLEAR-CELLS
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DOI：
10.1126/science.256.5064.1687
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发表时间：
1992-06-19
期刊：
影响因子：
56.9
通讯作者：
GIRARD, M
中科院分区：
文献类型：
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作者：
FULTZ, PN;NARA, P;GIRARD, M
由于人类免疫缺陷病毒 (HIV) 可以以无细胞病毒或受感染细胞（细胞相关病毒）的形式传播，因此疫苗必须防止这两种病毒形式的感染。疫苗介导的非人灵长类动物针对低剂量无细胞 HIV-1、HIV-2 或猿猴免疫缺陷病毒 (SIV) 的保护作用已得到证实。现在的研究表明，用 HIV-1 抗原对黑猩猩进行多次免疫可以防止细胞相关病毒的感染。保护作用可以持续很长一段时间（一只动物在攻击前一年没有接触过病毒抗原）。这些结果表明，有可能引发针对细胞相关 HIV-1 的持久保护性免疫。
Because human immunodeficiency virus (HIV) can be transmitted as cell-free virus or as infected cells (cell-associated virus), vaccines must protect against infection by both viral forms. Vaccine-mediated protection of nonhuman primates against low doses of cell-free HIV-1, HIV-2, or simian immunodeficiency virus (SIV) has been demonstrated. It is now shown that multiple immunizations of chimpanzees with HIV-1 antigens protected against infection with cell-associated virus. Protection can persist for extended periods (one animal had not been exposed to viral antigens for 1 year before challenge). These results show that it is possible to elicit long-lasting protective immunity against cell-associated HIV-1.