Transition-Metal-Free Coupling Annulation of Arynes with Ketones and Alkynoates: Assembly of Functionalized Naphthalenes.
Transition-Metal-Free Coupling Annulation of Arynes with Ketones and Alkynoates: Assembly of Functionalized Naphthalenes.
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DOI：
10.1021/acs.orglett.6b01782
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发表时间：
2016-07
期刊：
影响因子：
5.2
通讯作者：
Wen-Ming Shu;Kai-lu Zheng;Junrui Ma;A. Wu
中科院分区：
文献类型：
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作者：
Wen-Ming Shu;Kai-lu Zheng;Junrui Ma;A. Wu
芳烃、酮和炔酸酯的无过渡金属偶联环化反应已被证明。利用这种正式的[2 + 2 + 2]环加成反应，可以在一锅中高效地便捷地构建多种萘衍生物。此外，这种新颖且有效的环化已成功应用于1-菲酚衍生物的合成。
A transition-metal-free coupling annulation reaction of arynes, ketones, and alkynoates has been demonstrated. Using this formal [2 + 2 + 2] cycloaddition reaction, a wide variety of naphthalene derivatives were conveniently constructed in one pot with high efficiency. In addition, this novel and valid annulation has been successfully applied to the synthesis of 1-phenanthrenol derivatives.