Relationship between self-association of glycine molecules in supersaturated solutions and solid state outcome
Relationship between self-association of glycine molecules in supersaturated solutions and solid state outcome
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DOI：
10.1103/physrevlett.99.115702
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发表时间：
2007-09-14
影响因子：
8.6
通讯作者：
Myerson, Allan S.
中科院分区：
文献类型：
--
作者：
Erdemir, Deniz;Chattopadhyay, Soma;Myerson, Allan S.
小角X射线散射被用来直接检查形成的簇在过饱和溶液中的甘氨酸，试图了解他们的作用，在成核过程中。结果表明，大多数甘氨酸分子在水溶液中以二聚体形式存在，而在13%（v/v）乙酸-水混合物中以单体形式存在。由于水和乙酸-水溶液分别结晶成α和γ形式，研究结果表明溶液中的分子自缔合与多晶型产物之间存在直接相关性。
Small angle x-ray scattering is utilized to directly examine the formation of clusters in supersaturated solutions of glycine, in an attempt to understand their role in the nucleation process. The results suggest that the majority of glycine molecules exist as dimers in aqueous solutions, and monomers in 13% (v/v) acetic acid-water mixtures. As the water and acetic acid-water solutions crystallize into alpha and gamma forms, respectively, the findings indicate a direct correlation between molecular self-association in solution and the polymorphic outcome.