A comparison of multiple and single sleep latency and cerebral evoked potential (P300) measures in the assessment of excessive daytime sleepiness in narcolepsy-cataplexy.
A comparison of multiple and single sleep latency and cerebral evoked potential (P300) measures in the assessment of excessive daytime sleepiness in narcolepsy-cataplexy.
复制标题
多次和单次睡眠潜伏期和脑诱发电位（P300）测量在评估发作性睡病-猝倒患者白天过度嗜睡中的比较。
作者：
R. Broughton;M. Aguirre;W. Dunham
我们直接比较了诱发电位（EP）分量P3的振幅（通过P300范式），这是一种已知的与嗜睡相关的敏感EP，以及多次睡眠潜伏期测试（MSLT）的睡眠潜伏期测量（包括第1阶段或快速眼动[REM]和第2阶段或REM）。在标准MSLT小睡前，分别于上午10:00、中午12:00、下午2:00、下午4:00和下午6:00进行重复P3测量。通过判别分析和F检验，发现所有三种测量方法（P3和MSLT）都能区分两组的五次午睡数据，并且都显示出基本平行的昼夜节律时间效应，下午三点左右最困。然而，MSLT对于折叠的数据更强大。两种测试都错误地将一些受试者分类为属于另一组，对照组两种测试的错误分类更大，P3测量的错误分类更全面。结合MSLT治疗发作性睡病患者的两项睡眠起病快速眼动期（SOREMP）标准，1例患者仍归为正常。对单个小睡数据的分析表明，MSLT在区分群体方面比P3振幅强大得多，并且在所有五次小睡中都是如此。
A direct comparison was made between the amplitude of evoked potential (EP) component P3 (by the P300 paradigm), a known sensitive EP correlate of sleepiness, and sleep latency measures (both to stage 1 or rapid eye movement [REM] and to stage 2 or REM) of the Multiple Sleep Latency Test (MSLT) in 11 untreated narcoleptics and matched controls. Repeated P3 measures were performed immediately prior to standard MSLT naps at 10:00 a.m., 12:00 noon, 2:00 p.m., 4:00 p.m., and 6:00 p.m. Using discriminant analysis and F tests, all three measures (P3 and both by MSLT) were found to distinguish the two groups for collapsed five-nap data, and all showed essentially parallel circadian time-of-day effects, with greatest sleepiness in the midafternoon. The MSLT, however, was somewhat more powerful for collapsed data. Both tests misclassified some subjects as belonging to the other group, with greater misclassification for both tests in the control group and more overall for the P3 measure. Adding the two sleep onset REM period (SOREMP) criteria on MSLT for narcolepsy, one patient was still classified as normal. Analysis of data from individual naps indicated that the MSLT was considerably more powerful in discriminating groups than was P3 amplitude, and it did so for all five naps.