Health-related utility values of patients with primary Sjogren's syndrome and its predictors
Health-related utility values of patients with primary Sjogren's syndrome and its predictors
复制标题
DOI：
10.1136/annrheumdis-2012-202863
复制
发表时间：
2014-07-01
影响因子：
27.4
通讯作者：
Ng, Wan-Fai
中科院分区：
文献类型：
--
作者：
Lendrem, Dennis;Mitchell, Sheryl;Ng, Wan-Fai
目的EuroQol-5维度(EQ-5D)是一种测量健康相关生活质量的基于偏好的标准化工具，EQ-5D效用值可转换为质量调整寿命年(QALY)，以辅助成本效用分析。本研究旨在评估EQ-5D在英国639例原发性干燥综合征(PSS)患者中的实用价值。方法采用标准化形式收集的前瞻性数据与英国标准数据进行比较。结果PSS患者在活动、自理、日常活动、疼痛/不适、焦虑/抑郁等方面存在问题的比例分别为42.2%、16.7%、56.6%、80.6%和49.4%，而英国普通人群分别为5.4%、1.6%、7.9%、30.2%和15.7%。EQ-5D效用值的中位数为0.691(IQR为0.587~0.796，范围为-0.239~1.000)，呈双峰分布。双变量相关分析显示EQ-5D效用值与PSS的许多临床特征显著相关，但与疼痛、抑郁和疲劳的相关性最强(R值>；0.5)。在调整了年龄和性别差异后，多元回归分析确定疼痛和抑郁是EQ-5D效用值的两个最重要的预测因素，占变异性的48%。焦虑、疲劳和体重指数是其他有统计学意义的预测因素，但它们占了
Objectives EuroQoL-5 dimension (EQ-5D) is a standardised preference-based tool for measurement of health-related quality of life and EQ-5D utility values can be converted to quality-adjusted life years (QALYs) to aid cost-utility analysis. This study aimed to evaluate the EQ-5D utility values of 639 patients with primary Sjogren's syndrome (PSS) in the UK.Methods Prospective data collected using a standardised pro forma were compared with UK normative data. Relationships between utility values and the clinical and laboratory features of PSS were explored.Results The proportion of patients with PSS reporting any problem in mobility, self-care, usual activities, pain/discomfort and anxiety/depression were 42.2%, 16.7%, 56.6%, 80.6% and 49.4%, respectively, compared with 5.4%, 1.6%, 7.9%, 30.2% and 15.7% for the UK general population. The median EQ-5D utility value was 0.691 (IQR 0.587-0.796, range -0.239 to 1.000) with a bimodal distribution. Bivariate correlation analysis revealed significant correlations between EQ-5D utility values and many clinical features of PSS, but most strongly with pain, depression and fatigue (R values>0.5). After adjusting for age and sex differences, multiple regression analysis identified pain and depression as the two most important predictors of EQ-5D utility values, accounting for 48% of the variability. Anxiety, fatigue and body mass index were other statistically significant predictors, but they accounted for