Sensory Regeneration in Arthropods: Implications of Homoeosis and of Ectopic Sensilla
Sensory Regeneration in Arthropods: Implications of Homoeosis and of Ectopic Sensilla
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节肢动物的感觉再生：同质异形和异位感觉器的影响
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
J. Edwards
中科院分区：
文献类型：
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作者：
J. Edwards
概要。节肢动物神经系统中结合了严格的连通性和旺盛的再生这看似对立的属性。通过比较正常的胚胎后发育与再生（也仅限于未成熟阶段），这一明显的悖论在很大程度上得到了解决。神经元之间的生长和相互作用比想象的更加灵活，这一点也变得越来越明显。
正常的感觉原位再生在恢复失去的功能方面具有高度特异性。与胚胎发育一样，再生中的关键事件是外围和中心之间首次接触的建立。此后，再生遵循正常胚胎后发育的加速再现。
来自异位移植物、同源突变体和同源再生的数据解决了感觉发育和再生的四个组成部分：a) 表皮中的位置信息决定了受体类型和中心投射；b) 从外周到神经节的通道是非特异性的；异位神经元到达不匹配的神经节；c) 在神经堆内，特定投射是神经元的内在程序和表达为特定表面标记的通路之间相互作用的产物。目前对同色异谱片段测定的遗传基础的阐明以及作为途径标记的特定基因产物的鉴定为在分子水平上理解发育和再生中的神经特异性开辟了道路。
SYNOPSIS. The seemingly antithetic attributes of rigorous connectivity on one hand and vigorous regeneration on the other, are combined in the arthropod nervous system This apparent paradox is largely resolved by the comparison of normal postembryonic development with regeneration, which is also restricted to immature stages It is also becoming apparent that growth and interaction between neurons is more flexible than had been assumed.
Normal sensory regeneration in situ is highly specific in restoring lost function The crucial event in regeneration as in embryonic development, is the establishment of first contacts between periphery and center Thereafter regeneration follows an accelerated recapitulation of normal postembryonic development.
Data from ectopic grafts, homoeotic mutants and homoeotic regenerates address four components of sensory development and regeneration a) Positional information in the epidermis determines receptor type and central projection, b) Passage from periphery to ganglion is non specific Ectopic neurons reach mismatched ganglia c) Within neuropile the specific projection is a product of interaction between intrinsic programs of the neuron and pathways expressed as specific surface markers d) Fine tuning of synaptic relationships can occur in response to changed milieu The current elucidation of the genetic basis of metameric segment determination, and the identification of specific gene products as markers of pathways open the way to the understanding of neural specificity in development and regeneration at the molecular level.
感觉神经元移植和再生对蟋蟀中枢神经系统体位图的影响。
影响因子：
2.7
作者：
Murphey,RK;Johnson,SE;Walthall,WW
通讯作者：
Walthall,WW