Prognostic factors of outcome after radical cystectomy for bladder cancer: A retrospective study of a homogeneous patient cohort
Prognostic factors of outcome after radical cystectomy for bladder cancer: A retrospective study of a homogeneous patient cohort
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DOI：
10.1016/s0022-5347(05)68936-7
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发表时间：
1999-05-01
影响因子：
6.6
通讯作者：
Pagano, F
中科院分区：
文献类型：
--
作者：
Bassi, P;Ferrante, GD;Pagano, F
目的：由于文献中的数据很少，因此需要对接受根治性膀胱切除术的膀胱癌患者的预后进行病理学预测。我们回顾性分析了一个同质的和当代的一系列根治性手术治疗的患者作为单一的膀胱cancer.Materials和方法的独立预测因素：我们评估了369 535例膀胱癌根治性膀胱切除术，盆腔淋巴结清扫术和尿流改道治疗由同一个工作人员：在一个单一的机构之间的1982年2月和1994年2月。接受放疗和/或化疗的患者以及未接受正式盆腔淋巴结清扫的患者被排除在研究之外。结果：单因素分析显示，肿瘤分期、淋巴结转移、输尿管梗阻、血管、淋巴管和神经周围浸润是影响生存的预后因素（p < 0.05）。而只有肿瘤分期（P < 0.0000）和淋巴结转移（P <0.0001）
Purpose: Pathological predictors of outcome for patients undergoing radical cystectomy for bladder cancer are needed as few data are available in the literature. We retrospectively analyzed a homogeneous and contemporary series of patients treated with radical surgery as monotherapy for bladder cancer to identify the independent predictors of survival.Materials and Methods: We evaluated 369 of 535 patients with bladder cancer treated with radical cystectomy, pelvic node dissection and urinary diversion by the same staff: at a single institution between February 1982 and February 1994. Patients treated with radiation therapy and/or chemotherapy, and those who did not undergo formal pelvic node dissection were excluded from study. The end point of univariate and multivariate analyses was the overall 5-year survival.Results: Univariate analysis revealed that tumor stage, nodal involvement, ureteral obstruction, and vascular, lymphatic and perineural invasion were prognostic predictors of survival (p < 0.05). However, only tumor stage (p < 0.0000) and nodal involvement (p