Different effects of opiate withdrawal on dopamine turnover, uptake, and release in the striatum and nucleus accumbens.
Different effects of opiate withdrawal on dopamine turnover, uptake, and release in the striatum and nucleus accumbens.
复制标题
阿片戒断对纹状体和伏隔核多巴胺周转、摄取和释放的不同影响。
DOI：
10.1023/a:1022463029351
复制
发表时间：
1998
影响因子：
4.4
通讯作者：
Grasing,K
中科院分区：
文献类型：
--
作者：
Ghosh,S;Patel,AH;Cousins,M;Grasing,K
The purpose of these experiments was to further characterize changes in dopaminergic function that follow withdrawal from chronic opiate treatment. Withdrawal after treatment to a maximum dose of 120 mg/kg of morphine did not alter dopamine concentrations in the substantia nigra, ventral tegmental area, striatum, or nucleus accumbens; but did decrease concentrations of DOPAC and the ratio of DOPAC to dopamine in the lateral striatum and nucleus accumbens. Uptake of tritiated dopamine was diminished for withdrawn slices obtained from the striatum with no effect observed for tissue from the nucleus accumbens. Deficits of in vitro release of tritiated dopamine also occurred following withdrawal, with the nucleus accumbens being sensitive to dependence produced by a lower dose of morphine. In conclusion, opiate withdrawal produces a complex pattern of effects on dopaminergic function that is specific for the striatum and nucleus accumbens.
