Evidence of local exercise-induced systemic oxidative stress in chronic obstructive pulmonary disease patients
Evidence of local exercise-induced systemic oxidative stress in chronic obstructive pulmonary disease patients
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DOI：
10.1183/09031936.02.00014302
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发表时间：
2002-11-01
影响因子：
24.3
通讯作者：
Prefaut, C
中科院分区：
文献类型：
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作者：
Couillard, A;Koechlin, C;Prefaut, C
慢性不活动可能不是慢性阻塞性肺疾病（COPD）患者肌病的唯一因素。一种假设是，运动引起的氧化应激导致肌肉变化也可能参与其中。11名COPD患者（FEV11.15 +/-0.4L（平均值+/-SD））和12名年龄匹配的健康受试者进行了局限于外周肌群（优势腿的四头肌）的耐力运动，这些受试者具有相似的低体力活动量。作者测量了血浆中硫代巴比妥反应物质（TBAR）的水平，作为氧化应激的指标，超氧阴离子（O-2（.-））COPD患者的股四头肌耐力显著低于健康受试者（分别为136+/-16秒和385+/-69秒（平均值+/-SEM））。仅COPD患者股四头肌运动后6 h TBAR显著增加。此外，显著较高的O-2（.-）COPD患者在休息时的维生素E释放和血液维生素E水平低于对照组。COPD患者的血维生素E水平与静息状态下血浆TBAR水平显著相关。本研究主要表明，股四头肌运动诱导了慢性阻塞性肺疾病患者的全身氧化应激，并且这些患者在静息状态下的维生素E水平降低。这些发现与慢性阻塞性肺疾病肌病的确切相关性需要阐明。
Chronic inactivity may not be the sole factor involved in the myopathy of chronic obstructive pulmonary disease (COPD) patients. One hypothesis is that exercise-induced oxidative stress that leads to muscle alterations may also be involved. This study investigated whether exercise localised to a peripheral muscle group would induce oxidative stress in COPD patients.Eleven COPD patients (FEV1 1.15+/-0.4 L (mean+/-SD)) and 12 healthy age-matched subjects with a similar low quantity of physical activity performed endurance exercise localised to a peripheral muscle group, the quadriceps of the dominant leg. The authors measured plasma levels of thiobarbituric reactive substances (TBARs) as an index of oxidative stress, the release in superoxide anion (O-2(.-)) by stimulated phagocytes as an oxidant, and blood vitamin E as one antioxidant.Quadriceps endurance was significantly lower in the COPD patients compared with healthy subjects (136+/-16 s versus 385+/-69 s (mean+/-SEM), respectively). A significant increase in TBARs 6 h after quadriceps exercise was only found in the COPD patients. In addition, significantly higher O-2(.-) release and lower blood vitamin E levels were found in COPD patients than in controls at rest. This blood vitamin E level was significantly correlated with the resting level of plasma TBARs in the COPD patients.This study mainly showed that quadriceps exercise induced systemic oxidative stress in chronic obstructive pulmonary disease patients and that vitamin E levels were decreased in these patients at rest. The exact relevance of these findings to chronic obstructive pulmonary disease myopathy needs to be elucidated.