Biologically based analysis of the data for the Colorado uranium miners cohort: Age, dose and dose-rate effects
Biologically based analysis of the data for the Colorado uranium miners cohort: Age, dose and dose-rate effects
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DOI：
10.2307/3580219
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发表时间：
1999-10-01
影响因子：
3.4
通讯作者：
Moolgavkar, SH
中科院分区：
文献类型：
--
作者：
Luebeck, EG;Heidenreich, WF;Moolgavkar, SH
这项研究是一个全面的分析，最新的后续行动的科罗拉多铀矿工人队列使用两阶段克隆扩张模型，特别强调与年龄和暴露的影响。该模型提供了一个框架，其中肺癌死亡率的危害函数结合了详细的信息暴露于氡和氡子体从硬岩和铀矿开采以及吸烟的信息。尽管明确建模了吸烟对肺癌风险的影响，但发现了一个显着的出生队列效应，该效应显示队列中矿工的基线肺癌风险随出生年份线性增加。基于两阶段克隆扩增模型的分析表明，氡暴露影响中间细胞在癌症途径中的起始速率和中间细胞的增殖速率。然而，在对比的氡，这是非常显着的促进作用，氡的影响的启动率被发现是不显着的。该模型也被用来研究逆剂量率效应。这种影响对于矿井中典型的氡暴露是明显的，但预计会减弱，对于较长时间的暴露，甚至会逆转，对于较长时间和较低的家中氡暴露。该模型还预测了暴露停止后风险随时间的下降。对于居民暴露，肺癌风险与BEIR VI报告的估计值进行了比较。虽然风险估计值与居民研究得出的结果一致，但比BEIR VI报告中报告的风险估计值低约2至4倍。(C)1999年，辐射研究协会。
This study is a comprehensive analysis of the latest followup of the Colorado uranium miners cohort using the two-stage clonal expansion model with particular emphasis on effects related to age and exposure. The model provides a framework in which the hazard function for lung cancer mortality incorporates detailed information on exposure to radon and radon progeny from hard rock and uranium mining together with information on cigarette smoking. Even though the effect of smoking on lung cancer risk is explicitly modeled, a significant birth cohort effect is found which shows a linear increase in the baseline lung cancer risk with birth year of the miners in the cohort. The analysis based on the two-stage clonal expansion model suggests that exposure to radon affects both the rate of initiation of intermediate cells in the pathway to cancer and the rate of proliferation of intermediate cells. However, in contrast to the promotional effect of radon, which is highly significant, the effect of radon on the rate of initiation is found to be not significant. The model is also used to study the inverse dose-rate effect. This effect is evident for radon exposures typical for mines but is predicted to be attenuated, and for longer exposures even reversed, for the more protracted and lower radon exposures in homes. The model also predicts the drop in risk with time after exposure ceases. For residential exposures, lung cancer risks are compared with the estimates from the BEIR VI report. While the risk estimates are in agreement with those derived from residential studies, they are about two- to fourfold lower than those reported in the BEIR VI report. (C) 1999 by Radiation Research Society.