CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
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DOI：
10.1172/jci200114006
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发表时间：
2001-09-01
影响因子：
15.9
通讯作者：
Silverstein, RL
中科院分区：
文献类型：
--
作者：
Febbraio, M;Hajjar, DP;Silverstein, RL
CD 36在超过四分之一个世纪前被鉴定为血小板膜整合糖蛋白（糖蛋白IV），直到最近才被认为是血小板反应蛋白-1（TSP-1）的受体。TSP-1存在于ECM和血小板α颗粒中，它参与细胞附着、运动和增殖，以及蛋白酶活性、TGF-β激活、神经突生长和血管生成的调节（1）。最初，这种受体-配体对被证明介导血小板与单核细胞、肿瘤细胞和基质之间的相互作用。从那时起，CD 36已涉及多个生物过程，将其定义为多配体清道夫受体（参见参考文献2）。这些配体似乎非常多样化：除了TSP-1，它们还包括长链脂肪酸，修饰的LDL，视网膜光感受器外节，恶性疟原虫疟疾寄生的红细胞，镰状红细胞，阴离子磷脂，凋亡细胞和胶原蛋白I和IV。CD 36的生物学可以根据其在有或没有TSP-1的情况下介导的功能来广泛地划分，但是它可能与其他蛋白质（例如脂肪酸结合蛋白、小窝相关蛋白、整联蛋白、细胞骨架蛋白和信号分子）协同作用以实现其多种功能。
CD36, identified more than a quarter of a century ago as a platelet integral membrane glycoprotein (glycoprotein IV), was until recently best known as a receptor for thrombospondin-1 (TSP-1). TSP-1 is found in ECMs and platelet a granules, and it participates in cell attachment, motility and proliferation, as well as in modulation of protease activity, TGF-beta activation, neurite outgrowth, and angiogenesis (1). Initially, this receptor-ligand pair was shown to mediate interactions between platelets and monocytes, tumor cells, and matrix. Since then, CD36 has been implicated in multiple biological processes that define it as a multiligand scavenger receptor (see ref. 2 for review). These ligands appear remarkably diverse: In addition to TSP-1, they include long-chain fatty acids, modified LDL, retinal photoreceptor outer segments, Plasmodium falciparum malaria-parasitized erythrocytes, sickle erythrocytes, anionic phospholipids, apoptotic cells, and collagens I and IV. The biology of CD36 can be broadly divided in terms of functions that it mediates with or without TSP-1, but it is probable that it acts in concert with other proteins, such as fatty acid-binding proteins, caveola-associated proteins, integrins, cytoskeletal proteins, and signaling molecules, to effect its diverse functions.