Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma
Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma
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DOI：
10.5507/bp.2013.038
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发表时间：
2014-01-01
影响因子：
0.9
通讯作者：
Rozsival, Pavel
中科院分区：
文献类型：
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作者：
Lestak, Jan;Tintera, Jaroslav;Rozsival, Pavel
瞄准。目的：探讨高眼压性青光眼(HTG)和正常眼压性青光眼(NTG)患者的fMRI激活是否存在差异。样本包括8例不同阶段的高眼压性青光眼患者(女性3例，年龄41~65岁，男性5例，年龄40~73岁)和正常眼压性青光眼患者8例(女性6例，年龄53~70岁，男性2例，年龄40~52岁)。对照组8例，女性3例，年龄23~46岁，男性5例，年龄23~65岁。所有患者均接受了全面的眼科检查，包括视野、色觉和电生理功能。将结果与黑白(BW)和蓝/黄(BW)棋盘刺激后的fMRI图像进行比较，并进行统计学处理。作者分析了通过功能磁共振成像获得的图像中关于高眼压性青光眼和正常眼压性青光眼的研究结果。他们根据电生理检查得出结论，在高眼压性青光眼中，从视网膜神经节细胞到视觉皮质，整个视觉通路都会受到损害。在正常眼压性青光眼中，神经节细胞的反应相对正常。病理主要见于视觉通路。为此，作者对高眼压性青光眼患者和正常眼压性青光眼患者进行了功能磁共振检查。他们发现，高眼压性青光眼的进展期会导致fMRI活性下降。这些关系在正常眼压性青光眼患者中未观察到。同样，在高眼压性青光眼中，对黄/蓝刺激进行fMRI检查时，fMRI活动降低的程度大于黑/白刺激。在正常眼压性青光眼中未观察到类似的影响。从病因角度看，正常眼压性青光眼与高眼压性青光眼是不同的疾病。
Aim. The objective of our work was to determine whether there is a difference in fMRI activation between patients with high tension glaucoma (HTG) and those with normal tension glaucoma (NTG).Method. The sample consisted of eight patients with different stages of high tension glaucoma (3 females aged 41-65 and 5 males aged 40-73 years) and eight patients, also with different stages of normal tension glaucoma (6 females aged 53-70 and 2 males aged 40-52 years). The control group consisted of eight healthy subjects (3 females aged 23-46 and 5 males aged 23-65 years). All underwent complete ophthalmological examination, including visual field, colour vision, and electrophysiological functions. The results were compared with fMRI images after stimulation with black/white (BW) and blue/yellow (BY) checkerboard and then statistically processed.Results. The authors analyzed the results of published studies on high tension versus normal tension glaucoma in the images obtained by fMRI. They concluded on the basis of electrophysiological examinations that in high tension glaucoma, damage of the whole visual pathway occurs, starting from retinal ganglion cells up to the visual cortex. In normal tension glaucoma the response of ganglion cells is relatively normal. The pathology is found mainly in the visual pathway. For this reason, the authors carried out fMRI examinations in high tension glaucoma patients and patients with normal tension glaucoma. They found that advancing stages of high tension glaucoma cause progression of fMRI activity decrease. These relations were not observed in normal tension glaucoma cases. Similarly, in high tension glaucoma on fMRI examination to yellow/blue stimuli, the fMRI activity decrease was found to be greater than that to black/white stimulation. No similar effect was observed in normal tension glaucoma.Conclusion. Normal tension glaucoma is, from the etiopathogenetical view, a different disease than high tension glaucoma.