Structural analysis of the basal ganglia in schizophrenia
Structural analysis of the basal ganglia in schizophrenia
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DOI：
10.1016/j.schres.2006.08.031
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发表时间：
2007-01-01
影响因子：
4.5
通讯作者：
Csernansky, John G.
中科院分区：
文献类型：
--
作者：
Mamah, Daniel;Wang, Lei;Csernansky, John G.
据报道，精神分裂症中基底神经节结构的总体积增加。然而，基底神经节形状变化的模式（可以揭示子结构体积的局部变化）尚未得到研究。在这项研究中，比较了患有和不患有精神分裂症的受试者的几种基底神经节结构的总体积和形状。收集了 54 名精神分裂症患者和 70 名对照受试者的 T-1 加权磁共振扫描。高维（大变形）大脑绘图用于评估几个基底神经节结构的形状和体积。还评估了形状和体积测量与精神病理学、认知和运动功能的关系。将总脑体积作为协变量后，与对照受试者相比，精神分裂症受试者的尾状核和壳核的左右体积以及右侧苍白球体积显着增加。在将尾状核、壳核和苍白球的总体积作为协变量纳入后，形状上的显着差异伴随着尾状核、壳核和苍白球的体积变化。体积或形状测量与认知功能或临床症状之间几乎没有显着相关性，除了注意力/警觉认知维度与尾状核和壳核体积之间呈正相关，以及伏核体积与妄想之间呈负相关之外。 总之，精神分裂症受试者的基底神经节体积相对于大脑总体积比健康对照受试者更大。这些体积差异伴随着特定的形状变化模式。 (c) 2006 Elsevier B.V. 保留所有权利。
Increases in the total volume of basal ganglia structures have been reported in schizophrenia. However, patterns of basal ganglia shape change, which can reveal localized changes in Substructure volumes, have not been investigated. In this study, the total volume and shape of several basal ganglia structures were compared in subjects with and without schizophrenia.T-1-weighted magnetic resonance scans were collected in 54 schizophrenia and 70 comparison subjects. High-dimensional (large-deformation) brain mapping was used to assess the shape and volume of several basal ganglia structures. The relationships of shape and volume measures with psychopathology, cognition and motor function were also assessed.Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after total brain volume was included as a covariate. Significant differences in shape accompanied these volume changes in the caudate, putamen and globus pallidus, after their total volumes were included as covariates. There were few significant correlations between volume or shape measures and either cognitive function or clinical symptoms, other than a positive correlation between an attention/vigilance cognitive dimension and the volume of the caudate and putamen, and a negative correlation between nucleus accumbens volume and delusions.In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences. (c) 2006 Elsevier B.V. All rights reserved.