The Clinical Significance of Platelet‐Associated IgG: a Study on 298 Patients with Various Disorders
The Clinical Significance of Platelet‐Associated IgG: a Study on 298 Patients with Various Disorders
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血小板相关 IgG 的临床意义：对 298 名患有各种疾病的患者进行的研究
DOI：
10.1111/j.1365-2141.1980.tb05942.x
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发表时间：
1980
影响因子：
6.5
通讯作者：
M. Graubner
中科院分区：
文献类型：
--
作者：
C. Mueller;W. Kayser;K. Mersch;M. Breidenbach;H.‐G. Kugel And;M. Graubner
概括。通过定量血小板放射性抗 IgG 试验 (PRAT) 对 298 名患者进行了血小板相关 IgG (PAIgG) 的研究。在调查时，171 名患者患有血小板减少症（血小板计数 <100 × 109/1），127 名患者血小板计数正常。患者属于以下疾病类别：特发性血小板减少性紫癜（ITP）（N = 81），可能的ITP（19），急性ITP（9），系统性红斑狼疮（22），温型自身免疫性溶血性贫血（18），全身性血液疾病（65），肝脏疾病（35），其他（49）。所有疾病类别中均发现 PAIgG 显着升高。大多数疾病组的 PAIgG 与血小板计数倒数之间存在显着相关性。 PAIgG 和高丙种球蛋白状态（血清 IgG >1.8 g/l）之间没有明显的关系，血小板存活研究 (N=30) 显示 PAIgG 的正常和增加值与正常或缩短的血小板平均寿命相关。结论是，PAIgG 升高只是导致免疫介导的血小板减少症发生的几个因素之一。
Summary. Platelet‐associated IgG (PAIgG) was studied by a quantitative platelet radioactive anti‐IgG test (PRAT) in 298 patients. At the time of investigation, 171 patients were thrombocytopenic (platelet count <100 × 109/1), 127 had normal platelet counts. Patients fell into the following disease categories: Idiopathic thrombocytopenic purpura (ITP) (N=81), possible ITP (19), acute ITP (9), systemic lupus erythematosus (22), autoimmune haemolytic anaemia of warm‐type (18), systemic blood disease (65), liver diseases (35), others (49). A significant elevation of PAIgG was found in all disease categories. There was a significant correlation between PAIgG and the reciprocal values of platelet counts for most disease groups. No relationship was discernible between PAIgG and hypergammaglobulinaemic states (serum IgG >1.8 g/l), Platelet survival studies (N=30) revealed that normal and increased values of PAIgG were associated with normal or shortened platelet mean life span. It is concluded that an elevated PAIgG is only one of several factors involved in the development of immunologically mediated thrombocytopenia.