Role of Oxidative Stress in Drug-Induced Kidney Injury.
Role of Oxidative Stress in Drug-Induced Kidney Injury.
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DOI：
10.3390/ijms17111826
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发表时间：
2016-11-01
影响因子：
5.6
通讯作者：
Hosohata K
中科院分区：
文献类型：
--
作者：
Hosohata K
肾脏在维持体内平衡和解毒许多亲水性外源以及内源性化合物中起主要作用。由于肾小管上皮细胞通过管状有机离子转运体通过管状上皮细胞的管腔膜分泌离子药物，并通过过滤后的毒素重新吸收进入小管管腔，肾脏比其他器官暴露于更大比例和更高浓度的药物和毒素，因此这些细胞受到损伤的风险更大。事实上，药物性肾损伤是临床实践中的一个严重问题，约占住院患者急性肾损伤（AKI）病例的20%。因此，早期发现就显得尤为重要。通常，药物性AKI包括两种肾损伤模式：急性肾小管坏死（ATN）和急性间质性肾炎（AIN）。AIN是由引起过敏反应的药物引起的，而ATN是由对小管上皮细胞的直接毒性引起的。在ATN的多种细胞机制中，氧化应激通过促炎细胞因子的释放和组织中炎症细胞的积累激活炎症反应，在ATN的进展中起重要作用。本文综述了与AKI相关的药物，氧化应激在药物性AKI中的作用，以及以氧化应激为重点的药物性AKI的生物标志物。
The kidney plays a primary role in maintaining homeostasis and detoxification of numerous hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed to a larger proportion and higher concentration of drugs and toxins than other organs through the secretion of ionic drugs by tubular organic ion transporters across the luminal membranes of renal tubular epithelial cells, and through the reabsorption of filtered toxins into the lumen of the tubule, these cells are at greater risk for injury. In fact, drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20% of cases of acute kidney injury (AKI) among hospitalized patients. Therefore, its early detection is becoming more important. Usually, drug-induced AKI consists of two patterns of renal injury: acute tubular necrosis (ATN) and acute interstitial nephritis (AIN). Whereas AIN develops from medications that incite an allergic reaction, ATN develops from direct toxicity on tubular epithelial cells. Among several cellular mechanisms underlying ATN, oxidative stress plays an important role in progression to ATN by activation of inflammatory response via proinflammatory cytokine release and inflammatory cell accumulation in tissues. This review provides an overview of drugs associated with AKI, the role of oxidative stress in drug-induced AKI, and a biomarker for drug-induced AKI focusing on oxidative stress.
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影响因子：
2.3
作者：
Chatzikyrkou C;Hamwi I;Clajus C;Becker J;Hafer C;Kielstein JT
通讯作者：
Kielstein JT
影响因子：
19.6
作者：
Cortazar FB;Marrone KA;Troxell ML;Ralto KM;Hoenig MP;Brahmer JR;Le DT;Lipson EJ;Glezerman IG;Wolchok J;Cornell LD;Feldman P;Stokes MB;Zapata SA;Hodi FS;Ott PA;Yamashita M;Leaf DE
通讯作者：
Leaf DE
影响因子：
13.6
作者：
Davis, CA;Nick, HS;Agarwal, A
通讯作者：
Agarwal, A
影响因子：
5.3
作者：
Berruyer, C;Martin, FM;Galland, F
通讯作者：
Galland, F
影响因子：
56.9
作者：
DAVITZ, MA;HERELD, D;NUSSENZWEIG, V
通讯作者：
NUSSENZWEIG, V