Longitudinal change in FEV1 and FVC in chronic spinal cord injury.
Longitudinal change in FEV1 and FVC in chronic spinal cord injury.
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慢性脊髓损伤中 FEV1 和 FVC 的纵向变化。
DOI：
10.1164/rccm.200709-1332oc
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发表时间：
2008
影响因子：
24.7
通讯作者：
Garshick,Eric
中科院分区：
文献类型：
--
作者：
Stolzmann,KellyL;Gagnon,DavidR;Brown,Robert;Tun,CarlosG;Garshick,Eric
理论基础：虽然呼吸功能障碍在慢性脊髓损伤(SCI)中很常见，但FEV1和FVC纵向变化的决定因素尚未得到评估。目的：确定影响SCI纵向肺功能下降的因素。方法：共有174名男性参与者(平均年龄49岁，伤后17岁)完成了呼吸问卷，并接受了平均7.5年(4-14年)的随访。测量和主要结果：在多因素模型中，FEV1纵向下降与持续吸烟、持续喘息、身体质量指数增加和呼吸肌力量显著相关。年龄增长与FEV1的加速下降有关(40岁、40岁-60岁和60岁分别为−27、−37和−71毫升/年)。FVC也有类似的影响。结论：FEV1和FVC的纵向变化与SCI的程度和严重程度没有直接关系，但除了年龄外，还可能有可改变的因素。这些结果表明，控制体重，戒烟，针对喘息的识别和治疗的试验，以及努力改善呼吸肌力量，可能会减缓脊髓损伤后肺功能的下降。
Rationale: Although respiratory dysfunction is common in chronic spinal cord injury (SCI), determinants of longitudinal change in FEV1and FVC have not been assessed.Objectives: Determine factors that influence longitudinal lung function decline in SCI.Methods: A total of 174 male participants (mean age of 49 and 17 yr after injury) completed a respiratory questionnaire and underwent spirometry over an average follow-up of 7.5 years (range, 4–14 yr).Measurements and Main Results: In multivariate models, longitudinal decline in FEV1was significantly related to continued smoking, persistent wheeze, an increase in body mass index, and respiratory muscle strength. Aging was associated with an accelerated decline in FEV1(for ages <40, 40–60, >60 yr: −27, −37, and −71 ml/yr, respectively). Similar effects were observed for FVC.Conclusions: Longitudinal change in FEV1and FVC was not directly related to level and severity of SCI, but was attributable to potentially modifiable factors in addition to age. These results suggest that weight control, smoking cessation, trials directed at the recognition and treatment of wheeze, and efforts to improve respiratory muscle strength may slow lung function decline after SCI.