Identification of components of phospholipids metabolism in automated phosphate ester chromatography.
Identification of components of phospholipids metabolism in automated phosphate ester chromatography.
复制标题
自动磷酸酯色谱法中磷脂代谢成分的鉴定。
DOI：
10.1016/0006-291x(79)92077-1
复制
发表时间：
1979
影响因子：
3.1
通讯作者：
C. M. Roberts
中科院分区：
文献类型：
--
作者：
P. Geiger;C. M. Roberts
通过兔心室的自动磷酸酯色谱法，从非常早期的洗脱材料中分离和鉴定了两种化合物，甘油-3-磷酸胆碱和磷酸胆碱。这两种化合物（例如甘油-3-磷酸乙醇胺和磷酸乙醇胺）也占用高氯酸从成年大鼠和胚胎心脏以及许多其他组织中提取的材料的很大比例。自动磷酸酯色谱法应被证明在临床上可用于研究遗传性肌营养不良症等疾病，因为已知涉及上述化合物。
By means of automated phosphate ester chromatography of rabbit heart ventricles, two compounds, glycerol-3-phosphorylcholine and phosphocholine have been separated and identified from very early eluting material. These two compounds among others (glycerol-3-phosphoethanolamine and phosphoethanolamine for instance) also comprise a significant percentage of the material extracted with perchloric acid from rat adult and embryo hearts and many other tissues as well. Automated phosphate ester chromatography should prove clinically useful in studies of diseases such as hereditary muscular dystrophy as the compounds named are known to be involved.