A modification and validation of quantitative morphometry classification system for osteoporotic vertebral compressive fractures in mainland Chinese
A modification and validation of quantitative morphometry classification system for osteoporotic vertebral compressive fractures in mainland Chinese
复制标题
中国大陆骨质疏松性椎体压缩性骨折定量形态测量分类系统的修改和验证
DOI：
10.1007/s00198-018-4641-3
复制
发表时间：
2018-11-01
影响因子：
4
通讯作者：
Hu, Z. -A.
中科院分区：
文献类型：
--
作者：
Song, L. -J.;Wang, L. -L.;Hu, Z. -A.
本研究描述了一种适用于中国大陆人群特定参考值的改良定量形态测量（mQM）系统。使用Genant半定量系统对mQM系统进行了验证，该系统对于检测椎体高度变化和预测骨质疏松性椎体压缩性骨折（OVCF）患者经皮椎体后凸成形术（PKP）后的骨水泥泄漏是敏感的。为了提高骨质疏松症的临床治疗水平，定量形态测量（QM）系统在发达国家已被广泛用于OVCF的早期诊断和精确分类。在这里，我们提出了一个mQM系统，并验证其使用在检测OVCF在大陆chinese.MethodsUsing我们的mQM系统，椎体高度的术前和术后值进行了测量和评估，在309名中国大陆接受经皮椎体后凸成形术（PKP）OVCF治疗。通过与Genant半定量（SQ）方法获得的值进行比较，验证了mQM系统中骨折的测量和分类。此外，我们评估的敏感性的mQM系统，其能够检测恢复椎体高度和预测骨水泥泄漏后PKP.ResultsThe五个分类的骨折，无畸形（ND），前楔（AW），后楔（PW），双凹腔（BC），和压缩（CP），评估的mQM方法共享相似的分布特征相比，SQ方法。此外，mQM评估显示，PKP后所有骨折类型的椎体高度均显示出显著恢复。骨水泥渗漏发生率以CP最多（37.5%），其次为AW（31.6%）、BC（26.5%）、ND（23.7%）和PW（0.0%）。
aSummaryThis study described a modified quantitative morphometry (mQM) system adapted to specific reference values for Mainland Chinese population. The mQM system is validated using the Genant Semiquantative system and is sensitive for detecting vertebral height changes and predicting cement leakage after percutaneous kyphoplasty (PKP) in patients with osteoporotic vertebral compressive fracture (OVCF).IntroductionOVCF is a manifestation of osteoporosis. To improve clinical management of osteoporosis, the quantitative morphometry (QM) system has been widely used for the early diagnosis and precise classification of OVCF in developed countries. Here, we present an mQM system and validated its use in detecting OVCF in Mainland Chinese.MethodsUsing our mQM system, the pre- and post-operative values of vertebral heights were measured and evaluated in 309 Mainland Chinese who received percutaneous kyphoplasty (PKP) as OVCF treatment. Measurements and classification of fractures from the mQM system were validated by comparing to values obtained by the Genant semiquantative (SQ) method. Moreover, we evaluated the sensitivity of the mQM system by its ability to detect restoration of vertebral heights and predict cement leakage after PKP.ResultsThe five classification of fractures, No deformity (ND), anterior wedge (AW), posterior wedge (PW), biconcavity (BC), and compression (CP), evaluated by the mQM method shared similar distribution characteristics compared to those obtained by the SQ method. In addition, mQM evaluation showed that the vertebra height of all fracture types showed significant restoration after PKP. The incidence of cement leakage was most common in CP (37.5%), followed by AW (31.6%), BC (26.5%), ND (23.7%), and PW (0.0%).ConclusionsOur mQM system is suitable for classification of fractures, detection of vertebral height restoration, and correlation of cement leakage after PKP in Mainland Chinese population.