Monitoring the healing of a tibial osteotomy in the rabbit treated with external fixation.
Monitoring the healing of a tibial osteotomy in the rabbit treated with external fixation.
复制标题
监测接受外固定治疗的兔子胫骨截骨术的愈合情况。
DOI：
10.1002/jor.1100030309
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
White,AA
中科院分区：
文献类型：
--
作者：
Kaplan,SJ;Hayes,WC;Mudan,P;Lelli,JL;White,AA
在成年兔胫骨截骨愈合过程中，每周一次非损伤性监测骨折部位轴向刚度。实验分为两组，每组20只，分别用两种不同刚度的外固定器固定。分别于术后3、5、6、7、8周处死4只动物，测定骨折愈合失败时的弯矩。正常骨折愈合伴随着骨折部位轴向刚度发展的特征性阶段。从0到3周，有一段时间的低和近似恒定的刚度，随后在3到5周期间线性增加到约3到4倍的刚度。在6周时达到最大平均标准化轴向刚度，为未治疗对侧对照组的57%（高刚度组）和77%（低刚度组）。最大平均归一化失效力矩发生在8周时，分别为对照组的48%（高刚度）和44%（低刚度）。除了低刚度组在3周时失效力矩大幅增加外，固定器刚度引起的差异无统计学意义。轴向刚度与失效力矩相关（分别为r2= 0.74和0.53），但仅在前6周内。监测技术提供了一种非破坏性的手段，在动物模型中骨折愈合的生物力学进展。在3 - 5周时骨折部位轴向刚度特征性增加的发生也可用于区分正常愈合和异常愈合。
Fercture site axial rigidity was monitored nonestructively at weekly intervals during healing of tibial osteotomies in adult rabbits. Two groups of 20 rabbits each were treated with external fixators of two different rigidities. Four animals from each group were killed at 3,5,6,7, and 8 weeks to determine the bending moments at failure of the healing fractures. Normal fracture healing was accompanied by characteristic phases in the development of fracture site axial rigidity. From 0 to 3 weeks there was a period of low and approximately constant rigidity, followed by a linear increase during 3 to 5 weeks to an approximately three to four times greater rigidity. The maximum average normalized axial rigidities were reached at 6 weeks and were 57% (high rigidity group) and 77% (low rigidity group) of the untreated contralatreal controls. The Maximum average normalized failure moments occurred at 8 weeks and were 48% (high rigidity) and 44% (low rigidity) of controls. The differences due to fixator rigidity were not statistically significant except for a large increse in failure moments at 3 weeks for the low rigidity group. Axial rigidities were correlated (r2= 0.74 and 0.53, respectively) with failure moments, but only during the first 6 weeks. The monitoring technique provides a nondestructive means for following the biomechanical progress of fracture healing in in an animal model. The occurrence of the characteristic increase in fracture site axial rigidity at 3 to 5 weeks can also be used to distinguish between normal and abnormal healing.