Overproduction and elimination of retinal axons in the fetal rhesus monkey.
Overproduction and elimination of retinal axons in the fetal rhesus monkey.
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DOI：
10.1126/science.6828871
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发表时间：
1983-03
期刊：
影响因子：
56.9
通讯作者：
P. Rakić;K. P. Riley
中科院分区：
文献类型：
--
作者：
P. Rakić;K. P. Riley
定量电子显微镜分析显示，恒河猴胎儿中有285万个视网膜轴突，这个数字是成年猴120万个的两倍多。超过100万个多余的视神经轴突在出生前被消除，同时将来自两只眼睛的输入分离到外侧膝状体核的不同层中。视神经轴突的选择性消除可能不仅在双眼视觉连接的分离中发挥作用，而且其次，可能建立交叉和非交叉retinogeniculate投射的比例。
Quantitative electron microscopic analysis reveals 2.85 million retinal axons in fetal rhesus monkeys--a number that is more than twice the 1.2 million present in the adult. More than 1 million supernumerary optic axons are eliminated before birth, simultaneously with the segregation of inputs from the two eyes into separate layers of the lateral geniculate nucleus. Selective elimination of optic axons may not only play a role in the segregation of binocular visual connections but, secondarily, may establish the ratio of crossed and uncrossed retinogeniculate projections.