Evaluation of Salivary and Serum Antioxidant and Oxidative Stress Statuses in Patients with Chronic Periodontitis: A Case-Control Study.
Evaluation of Salivary and Serum Antioxidant and Oxidative Stress Statuses in Patients with Chronic Periodontitis: A Case-Control Study.
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DOI：
10.3389/fphys.2017.00189
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发表时间：
2017
影响因子：
4
通讯作者：
Kebriaei R
中科院分区：
文献类型：
--
作者：
Ahmadi-Motamayel F;Goodarzi MT;Jamshidi Z;Kebriaei R
目的：牙周炎局部细菌刺激中性粒细胞释放活性氧。氧化应激水平的增加在牙周炎的发病机制中起着重要作用。因此，本研究旨在评估慢性牙周炎患者唾液和血清总抗氧化能力和丙二醛。材料和方法：55名健康受试者和55名慢性牙周炎患者，年龄范围为30-50岁，进行了评估。在临床检查和病例选择后，在早晨收集未刺激的全唾液。从肘前静脉采集血样。总抗氧化能力和丙二醛水平通过分光光度法测定。采用Stata.11软件进行t检验。结果：牙周炎组唾液和血清总抗氧化能力分别为0.16和0.36，均低于对照组（P = 0.11）。病例组和对照组的平均唾液丙二醛水平分别为0.80 ± 0.09和0.42 ± 0.08。结果表明，牙周炎组唾液和血清中丙二醛水平明显高于对照组。性别对抗氧化剂和氧化应激水平没有任何影响。结论：慢性牙周炎患者唾液和血清氧化应激水平升高。这些患者的唾液和血清中的总抗氧化能力略低。在这些患者中，较高的丙二醛水平和抗氧化状态无变化可导致全身和局部并发症。
Aim: Local bacteria stimulate polymorphonuclear neutrophils to release reactive oxygen species in periodontitis. Increased levels of oxidative stress play a significant role in the pathogenesis of periodontitis. Therefore, this study aimed to evaluate total salivary and serum antioxidant capacity and malondialdehyde in patients with chronic periodontitis. Materials and methods: Fifty-five healthy subjects and 55 patients with chronic periodontitis, with an age range of 30–50 years, were evaluated. After clinical examination and case selection, unstimulated whole saliva was collected in the morning. Blood samples were taken from the antecubital vein. Total antioxidant capacity and malondialdehyde levels were evaluated by spectrophotometric assay. Data were analyzed with t-test, using Stata.11 software program. Results: The periodontitis group exhibited lower salivary (0.16) and serum (0.36) total antioxidant capacity (P = 0.11) compared to the control group. Mean salivary malondialdehyde levels in the case and control groups were 0.80 ± 0.09 and 0.42 ± 0.08, respectively. The results showed significantly higher levels of salivary and serum malondialdehyde in the periodontitis group. Gender did not have any effect on antioxidant and oxidative stress levels. Conclusion: This study indicated increased levels of salivary and serum oxidative stresses in patients with chronic periodontitis. Total antioxidant capacity was mildly lower in the saliva and serum of these patients. Higher malondialdehyde levels with no changes in antioxidant status can result in systemic and local complications in these patients.