Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein
Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein
复制标题
DOI：
10.1159/000053260
复制
发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Honjo, M
中科院分区：
文献类型：
--
作者：
Asada, N;Takahashi, Y;Honjo, M
方法：利用高效表达人生长激素受体的3T3-L1-hGHR脂肪细胞，研究在有或无人生长激素结合蛋白(HGHBP)作用下，人生长激素(HGH)对瘦素产生和脂解刺激的影响。结果与结论：(1)hGH抑制hGH诱导的脂解刺激后瘦素的分泌；(2)hGHBP可减弱22K hGH对瘦素生成和脂解刺激的抑制作用，而22K hGH的天然异构体20K hGH对瘦素分泌和脂解刺激的抑制作用不受hGHBP的影响。版权所有(C)2001 S.Karger AG。巴塞尔。
Method: We studied the effects of human growth hormone (hGH) on leptin production and lipolysis stimulation in the presence or absence of human growth hormone binding protein (hGHBP) using 3T3-L1-hGHR adipocytes which efficiently express human growth hormone receptor. Results and Conclusion: It was clarified that (1) hGH decreases leptin secretion after hGH-induced lipolysis stimulation, and (2) the reduction of leptin production and lipolysis stimulation by 22K hGH was attenuated with hGHBP, whereas that by 20K hGH, which is a naturally occurring isoform of 22K hGH, was not affected with hGHBP. Copyright (C) 2001 S. Karger AG. Basel.