Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study
Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study
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DOI：
10.1093/ndt/gfac288
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发表时间：
2022-10-16
影响因子：
6.1
通讯作者：
Sawada, Norie
中科院分区：
文献类型：
--
作者：
Miyamoto, Yoshihisa;Katagiri, Ryoko;Sawada, Norie
尽管研究发现慢性肾脏病（CKD）和癌症发病率之间存在关联，但结果并不一致。方法本研究包括日本公共卫生中心前瞻性研究的参与者，他们有血清肌酐测量数据。我们在日本进行了一项系统性调查，评估了估计肾小球滤过率（eGFR）与总癌症发病率和特定部位癌症发病率风险之间的关系。我们估计了风险比（HR）和95%置信区间（CI），并对参与者的人口统计学和生活方式因素进行了调整。结果21978例符合纳入标准的受试者接受了平均12.9年的随访，期间共报告了2997例癌症事件。在多变量校正模型中，eGFR ≥ 90 mL/min/1.73 m（2）为1.10（95% CI 1.00-1.22）。结论：在这项大型前瞻性研究中，低eGFR与CKD患者总癌症发病率风险增加无显著相关性，这可能部分是由于样本量不足。这一发现可能是由于CKD和癌症之间有许多共同的风险因素。
Background Although studies have found an association between chronic kidney disease (CKD) and cancer incidence, the results are inconsistent. Methods This study included participants in the Japan Public Health Center-based Prospective Study who had data on serum creatinine measurements. We assessed the association between estimated glomerular filtration rate (eGFR) and the risk of total and site-specific cancer incidence using a systematic survey in Japan. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for participant demographics and lifestyle factors. Results A total of 21 978 participants who met the inclusion criteria were followed up for a mean period of 12.9 years, during which a total of 2997 incident cancer cases were reported. In the multivariable adjusted models, an eGFR of = 90 mL/min/1.73 m(2) was 1.10 (95% CI 1.00-1.22). Conclusions In this large prospective study, a low eGFR was not significantly associated with an increased risk of total cancer incidence in patients with CKD, which may be partly due to an underpowered sample size. This finding may be due to the many shared risk factors between CKD and cancer.