Leptin is essential in maintaining normal vascular compliance independent of body weight.
Leptin is essential in maintaining normal vascular compliance independent of body weight.
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瘦素对于维持正常的血管顺应性（与体重无关）至关重要。
DOI：
10.1038/ijo.2009.208
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Barouch,LA
中科院分区：
文献类型：
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作者：
Sikka,G;Yang,R;Reid,S;Benjo,A;Koitabashi,N;Camara,A;Baraban,E;O'Donnell,CP;Berkowitz,DE;Barouch,LA
脂肪细胞因子瘦素通过提高代谢率和发出饱腹感信号来集中调节体重，但它也具有广泛的外周效应。瘦素受体在血管平滑肌细胞上表达，具有维持血管张力的作用。我们研究了瘦素补充或热量限制对瘦素缺陷小鼠 (ob/ob) 和瘦素拮抗剂对野生型 (WT) 小鼠的血管影响。通过无创多普勒测量脉搏波速度来评估主动脉顺应性；通过左心室导管插入术测量血压。我们发现，ob/ob 小鼠的主动脉比 WT 小鼠更僵硬，并且尽管体重减轻相似，但用瘦素治疗的 ob/ob 小鼠与热量限制治疗相比，主动脉僵硬度的降低更大。有趣的是，用瘦素拮抗剂治疗WT小鼠会增加主动脉僵硬度，但体重没有变化。因此，我们得出结论，瘦素对于维持正常的主动脉顺应性（独立于体重）至关重要。
The adipocytokine leptin centrally regulates body weight by enhancing metabolic rate and signaling satiety, but it also has wide-ranging peripheral effects. Leptin receptors are expressed on vascular smooth muscle cells and have a role in maintaining vascular tone. We investigated the vascular effects of leptin repletion or calorie restriction on leptin-deficient mice (ob/ob) and a leptin antagonist on wild-type (WT) mice. Aortic compliance was assessed by the measurement of pulse wave velocity by noninvasive Doppler; blood pressure was measured by left ventricular catheterization. We found that ob/ob mice have much stiffer aortas than WT mice and that reduction in aortic stiffness was greater in ob/ob mice treated with leptin vs calorie restriction, despite similar weight loss. Interestingly, treating WT mice with a leptin antagonist increases aortic stiffness with no change in weight. Thus, we conclude that leptin is essential for maintaining normal aortic compliance independent of body weight.